C5490
C75
≥98% (HPLC), fatty acid synthase (FAS) inhibitor of, powder
Synonym(s):
4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C14H22O4
CAS Number:
Molecular Weight:
254.32
UNSPSC Code:
41121801
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
C75, ≥98% (HPLC), powder
SMILES string
CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
InChI key
VCWLZDVWHQVAJU-UHFFFAOYSA-N
InChI
1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Application
C75 has been used:
- as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
- as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
- as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide
Biochem/physiol Actions
C75 helps to increase the cancer‐killing capability of ionizing radiation.
C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence
Kim YM, et al.
Test, 285(38), 29069-29077 (2010)
Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b
Wahdan-Alaswad RS, et al.
Hormones & Cancer, 5(6), 374-389 (2014)
Yuta Sakae et al.
Biology open, 9(4) (2020-04-09)
The teleost fish, medaka (Oryzias latipes), employs the XX/XY genetic sex determination system. We show here that the phenotypic sex of medaka is affected by changes in lipid metabolism. Medaka larvae subjected to 5 days of starvation underwent female-to-male sex reversal.
Song-Hyo Jin et al.
PLoS neglected tropical diseases, 11(6), e0005687-e0005687 (2017-06-22)
Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in
Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75
Rae C, et al.
Chirality, 29(1), 10-13 (2017)
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