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N7758

Naloxone hydrochloride dihydrate

Name: Naloxone hydrochloride dihydrate
Brand: SIGMA

≥98% (TLC and titration), μ, κ, δ, and σ opioid receptor antagonist, powder

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₁NO₄ · HCl · 2H₂O

CAS Number:

51481-60-8

Molecular Weight:

399.87

NACRES:

NA.77

PubChem Substance ID:

24278050

UNSPSC Code:

12352200

MDL number:

MFCD00150901

Beilstein/REAXYS Number:

6260807

Assay:

≥98% (TLC and titration)

Form:

powder

Quality level:

200

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Properties

Product Name

Naloxone hydrochloride dihydrate, ≥98% (TLC and titration), powder

Quality Level

200

assay

≥98% (TLC and titration)

form

powder

optical activity

[α]25/D −178.6°, c = 2.5 in H₂O(lit.)

color

white to off-white

solubility

ethanol: 3.3 mg/mL, H₂O: 50 mg/mL

storage temp.

2-8°C

SMILES string

O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C

InChI

1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1

InChI key

TXMZWEASFRBVKY-IOQDSZRYSA-N

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Description

Application

Naloxone hydrochloride dihydrate has been used in:

isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
as a reference neutral antagonist to define the maximum effect (Emax) of the system

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Light sensitive.

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000537932

0000486132

0000486134

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