P2371
Pamidronate disodium salt hydrate
≥95% (NMR), Bone resorption inhibitor, solid
Synonym(s):
3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate
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About This Item
Empirical Formula (Hill Notation):
C3H9NO7P2Na2 · xH2O
CAS Number:
Molecular Weight:
279.03 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
260-647-1
MDL number:
Product Name
Pamidronate disodium salt hydrate, ≥95% (NMR), solid
InChI key
TVQNUQCYOOJTMK-UHFFFAOYSA-L
InChI
1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2
SMILES string
O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O
assay
≥95% (NMR)
form
solid
color
white
mp
300 °C
solubility
H2O: 28 mg/mL
originator
Novartis
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).
Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Ratna Chatterjee et al.
British journal of haematology, 159(4), 462-471 (2012-09-13)
This study aimed to evaluate bone remodelling disorders in thalassaemia by using pamidronate (PD) infusion with or without hormone replacement therapy (HRT) as a diagnostic-therapeutic tool. In this prospective study, 24 adult thalassaemia major (TM) and 10 thalassaemia intermedia (TI)
Marcin Kos et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(6), 1010-1016 (2013-03-16)
Bacterial colonization of the denuded bone in bisphosphonate-related osteonecrosis of the jaw suggests that bisphosphonates increase bacterial adhesion and biofilm formation. This study evaluated the adhesion of gram-positive and gram-negative bacteria on hydroxyapatite coated with pamidronate, one of the most
Coralie Leblicq et al.
Pediatric blood & cancer, 60(5), 741-747 (2012-09-25)
Osteonecrosis (ON) is a severe complication of acute lymphoblastic leukemia (ALL) treatments. Recent studies suggest that bisphosphonates might reduce pain and loss of motor function in patients with ON. We assessed the effects of pamidronate compared to standard care in
Uncomplicated vaginal delivery in two consecutive pregnancies carried to term in a woman with osteogenesis imperfecta type I and bisphosphonate treatment before conception.
Chih-Ping Chen et al.
Taiwanese journal of obstetrics & gynecology, 51(2), 305-307 (2012-07-17)
Alexandre Loupy et al.
The Journal of clinical investigation, 122(9), 3355-3367 (2012-08-14)
Tight regulation of calcium levels is required for many critical biological functions. The Ca2+-sensing receptor (CaSR) expressed by parathyroid cells controls blood calcium concentration by regulating parathyroid hormone (PTH) secretion. However, CaSR is also expressed in other organs, such as
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