SAB4502982
Anti-TNFA antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Cachectin, TNF-α, TNF-a, Tumor necrosis factor, Tumor necrosis factor ligand superfamily member 2
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About This Item
Product Name
Anti-TNFA antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 25 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TNF(7124)
Biochem/physiol Actions
The TNFA (tumor necrosis factor α) gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Anti-TNFA Antibody detects endogenous levels of total TNFA protein.
The TNFA (tumor necrosis factor α) gene is mapped to human chromosome 6p21.33 and codes for a pro-inflammatory cytokine.
Immunogen
The antiserum was produced against synthesized peptide derived from human TNFA.
Immunogen Range: 141-190
Immunogen Range: 141-190
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Roosmarijn E Vandenbroucke et al.
EMBO molecular medicine, 5(7), 1000-1016 (2013-06-01)
Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases. We observed that MMP13(-/-) mice display a strong protection
Máté Bencsics et al.
Frontiers in immunology, 14, 1135410-1135410 (2023-07-17)
T cell-dependent inflammatory response with the upregulation of helper 17 T cells (Th17) and the downregulation of regulatory T cells (Treg) accompanied by the increased production of tumor necrosis alpha (TNFa) is characteristic of inflammatory bowel diseases (IBD). Modulation of
Inflammatory cytokine production in tumor cells upon chemotherapy drug exposure or upon selection for drug resistance
Edwardson D.W
PLoS ONE, 12(9), 1-32 (2017)
Zhuo-Ying Tao et al.
Cancer research communications, 4(2), 418-430 (2024-02-07)
Intratumoral nerve infiltration relates to tumor progression and poor survival in oral squamous cell carcinoma (OSCC). How neural involvement regulates antitumor immunity has not been well characterized. This study aims to investigate molecular mechanisms of regulating tumor aggressiveness and impairing
Mahmoud Elashiry et al.
Journal of extracellular vesicles, 9(1), 1795362-1795362 (2020-09-19)
Chronic bone degenerative diseases represent a major threat to the health and well-being of the population, particularly those with advanced age. This study isolated exosomes (EXO), natural nano-particles, from dendritic cells, the "directors" of the immune response, to examine the
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