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860812P

Avanti

12:0(2S-OH) Ceramide

Name: 12:0(2S-OH) Ceramide
Brand: AVANTI

Avanti Research^™ - A Croda Brand

Synonym(s):

N-(2′-(S)-hydroxylauroyl)-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₅₉NO₄

CAS Number:

1246298-45-2

Molecular Weight:

497.79

MDL number:

MFCD22416670

UNSPSC Code:

12352211

NACRES:

NA.25

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Properties

Product Name

12:0(2S-OH) Ceramide, Avanti Research^™ - A Croda Brand 860812P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (860812P-5mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand 860812P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@@H](O)CCCCCCCCCC)=O)CO

InChI

1S/C30H59NO4/c1-3-5-7-9-11-13-14-15-16-17-19-20-22-24-28(33)27(26-32)31-30(35)29(34)25-23-21-18-12-10-8-6-4-2/h22,24,27-29,32-34H,3-21,23,25-26H2,1-2H3,(H,31,35)/b24-22+/t27-,28+,29-/m0/s1

InChI key

CPDJNFOAARXMMT-NGXZUFBYSA-N

Description

General description

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis. 12:0(2S-OH) Ceramide is a 2S hydroxylated lauric acid-containing ceramide.

Biochem/physiol Actions

Hydroxy fatty acid (hFA)-sphingolipids facilitate cell signaling. hFA-ceramides contribute to the permeability barrier function of the epidermis. Synthesis of hFA-ceramides are catalyzed by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes nervous system disorders leukodystrophy and spastic paraparesis in humans. An antitumor drug, PM02734 requires hFA-ceramides in the cell membrane to exhibit its activity.

Packaging

5 mL Amber Glass Screw Cap Vial (860812P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

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