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860815P

Avanti

16:0(2R-OH) Ceramide

Name: 16:0(2R-OH) Ceramide
Brand: AVANTI

Avanti Research^™ - A Croda Brand

Synonym(s):

N-(2′-(R)-hydroxypalmitoyl)-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):

C₃₄H₆₇NO₄

CAS Number:

34839-02-6

Molecular Weight:

553.90

MDL number:

MFCD22416671

UNSPSC Code:

12352211

NACRES:

NA.25

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Properties

Product Name

16:0(2R-OH) Ceramide, Avanti Research^™ - A Croda Brand 860815P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (860815P-25mg), pkg of 1 × 5 mg (860815P-5mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand 860815P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCC)=O)CO

InChI key

YWZGQPJRQXHVQX-GGMPIESISA-N

Description

General description

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis. 16:0(2R-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in R configuration.

Biochem/physiol Actions

Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling. They may also help in regulation of cell differentiation and apoptosis. Synthetic 2′R-hydroxy-C16-ceramide exhibits high proapoptotic activity than proapoptotic 2′S-hydroxy-C16-ceramide. hFA-ceramides in epidermis support permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes neurological disorders including, leukodystrophy and spastic paraparesis in humans. The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.

Packaging

5 mL Amber Glass Screw Cap Vial (860815P-25mg)

5 mL Amber Glass Screw Cap Vial (860815P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

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