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860816P

Avanti

16:0(2S-OH) Ceramide

Name: 16:0(2S-OH) Ceramide
Brand: AVANTI

Avanti Research^™ - A Croda Brand

Synonym(s):

N-(2′-(S)-hydroxypalmitoyl)-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):

C₃₄H₆₇NO₄

CAS Number:

890041-50-6

Molecular Weight:

553.90

MDL number:

MFCD22416672

UNSPSC Code:

12352211

NACRES:

NA.25

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Properties

Product Name

16:0(2S-OH) Ceramide, Avanti Research^™ - A Croda Brand 860816P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (860816P-5mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand 860816P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@@H](O)CCCCCCCCCCCCCC)=O)CO

InChI

1S/C34H67NO4/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-32(37)31(30-36)35-34(39)33(38)29-27-25-23-21-18-16-14-12-10-8-6-4-2/h26,28,31-33,36-38H,3-25,27,29-30H2,1-2H3,(H,35,39)/b28-26+/t31-,32+,33-/m0/s1

InChI key

YWZGQPJRQXHVQX-UMKNRRHWSA-N

Description

General description

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis. 16:0(2S-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in S configuration.

Biochem/physiol Actions

Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling. They also facilitate cell differentiation and apoptosis. hFA-ceramides in epidermis help in permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H leads to the development of neurological disorders including leukodystrophy and spastic paraparesis in humans. hFA-ceramides in the cell membrane are essential for PM02734 drug to exhibit its anti-tumor activity.

Packaging

5 mL Amber Glass Screw Cap Vial (860816P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

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