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860817P

Avanti

17:0(2R-OH) Ceramide

Name: 17:0(2R-OH) Ceramide
Brand: AVANTI

Avanti Research^™ - A Croda Brand

Synonym(s):

N-(2′-(R)-hydroxyheptadecanoyl)-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):

C₃₅H₆₉NO₄

CAS Number:

1246298-46-3

Molecular Weight:

567.93

MDL number:

MFCD22416673

UNSPSC Code:

12352211

NACRES:

NA.25

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Properties

Product Name

17:0(2R-OH) Ceramide, Avanti Research^™ - A Croda Brand 860817P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (860817P-5mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand 860817P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCCC)=O)CO

InChI

1S/C35H69NO4/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(38)32(31-37)36-35(40)34(39)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,32-34,37-39H,3-26,28,30-31H2,1-2H3,(H,36,40)/b29-27+/t32-,33+,34+/m0/s1

InChI key

MBKBHFOACJJHAN-NBVWUYLUSA-N

Description

General description

17:0(2R-OH) Ceramide is a 2R hydroxylated heptadecanoic acid-containing sphingolipid. It is present mainly in epidermis.

Biochem/physiol Actions

Hydroxy fatty acids (hFA)-sphingolipids play a vital role in cell signaling. They also help in cell differentiation and apoptosis. hFA-ceramides are involved in the formation of the epidermal barrier. Fatty acid 2-hydroxylases (FA2H) synthesize hFA-ceramides. Mutations of FA2H have been linked to neurological disorders like spastic paraparesis in humans and leukodystrophy. hFA-ceramides in the cell membrane play a crucial role in imparting the PM02734 drug with anti-tumor activity.

Packaging

5 mL Amber Glass Screw Cap Vial (860817P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

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