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About This Item
Empirical Formula (Hill Notation):
C36H69NO4
CAS Number:
Molecular Weight:
579.94
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
18:1(2S-OH) Ceramide, Avanti Research™ - A Croda Brand 860828P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860828P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860828P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@@H](O)CCCCCC/C=C\CCCCCCCC)=O)CO
InChI key
OGMXRWJJGUINGB-GRQDMSQNSA-N
General description
18:1(2S-OH) Ceramide is a 2S hydroxylated oleic acid-containing sphingolipid. hFA- ceramides are mainly found in epidermis.
Biochem/physiol Actions
Ceramides containing hydroxy fatty acids play a vital role in epidermal permeability barrier function.
Packaging
5 mL Amber Glass Screw Cap Vial (860828P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Hiroko Hama
Biochimica et biophysica acta, 1801(4), 405-414 (2009-12-23)
2-Hydroxy fatty acids (hFA) are important components of a subset of mammalian sphingolipids. The presence of hFA in sphingolipids is best described in the nervous system, epidermis, and kidney. However, the literature also indicates that various hFA-sphingolipids are present in
Nathan L Alderson et al.
Journal of lipid research, 50(6), 1203-1208 (2009-01-28)
Sphingolipids are ubiquitous components of eukaryotic cells that regulate various cellular functions. In many cell types, a fraction of sphingolipids contain 2-hydroxy fatty acids, produced by fatty acid 2-hydroxylase (FA2H), as the N-acyl chain of ceramide [hydroxyl fatty acid (hFA)-sphingolipids].
Ana B Herrero et al.
Cancer research, 68(23), 9779-9787 (2008-12-03)
PM02734 is a novel synthetic antitumor drug that is currently in phase I clinical trials. To gain some insight into its mode of action, we used the yeast Saccharomyces cerevisiae as a model system. Treatment of S. cerevisiae with PM02734