553211
Rapamycin
≥95% (HPLC), solution, mTOR inhibitor, Calbiochem
Synonym(s):
InSolution Rapamycin, mTOR Inhibitor I
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About This Item
Empirical Formula (Hill Notation):
C51H79NO13
Molecular Weight:
914.17
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solution
Quality level:
Storage condition:
desiccated (hygroscopic), protect from light
Product Name
Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
Quality Level
assay
≥95% (HPLC)
form
solution
manufacturer/tradename
Calbiochem®
storage condition
desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
General description
Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Mammalian target of rapamycin (mTOR)
Mammalian target of rapamycin (mTOR)
Product does not compete with ATP.
Reversible: no
Target IC50: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase
Packaging
Packaged under inert gas
Physical form
2.5 mg/mL solution in DMSO (2.74 mM)
Preparation Note
Following initial use, aliquot and freeze (-20°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
Certificates of Analysis (COA)
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Rachel M Wise et al.
Cells, 9(10) (2020-10-04)
Human adipose-derived stem cells (ASCs) show immense promise for treating inflammatory diseases, attributed primarily to their potent paracrine signaling. Previous investigations demonstrated that short-term Rapamycin preconditioning of bone marrow-derived stem cells (BMSCs) elevated secretion of prostaglandin E2, a pleiotropic molecule
Autophagy regulates sex steroid hormone synthesis through lysosomal degradation of lipid droplets in human ovary and testis.
Esmaeilian, et al.
Cell Death & Disease, 14, 342-342 (2023)
Clarissa Braun et al.
Cell stress, 5(12), 176-182 (2021-12-18)
Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory processes. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (mTORC1). However, additional pathways that