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Merck

G7776

Glutaraldehyde solution

Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use

Synonym(s):

Glutaric dialdehyde solution, Pentane-1,5-dial

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About This Item

Linear Formula:
OHC(CH2)3CHO
CAS Number:
111-30-8
Molecular Weight:
100.12
UNSPSC Code:
12352114
NACRES:
NA.21
PubChem Substance ID:
24895322
MDL number:
MFCD00007025
Beilstein/REAXYS Number:
605390

Product Name

Glutaraldehyde solution, Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use

InChI

1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2

SMILES string

[H]C(CCCC([H])=O)=O

InChI key

SXRSQZLOMIGNAQ-UHFFFAOYSA-N

type

Grade I

form

liquid

concentration

70% in H2O

technique(s)

electron microscopy: suitable (fixative)

color

colorless

solubility

water: soluble

storage temp.

2-8°C

Quality Level

200

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Application

Glutaraldehyde solution has been used as a fixative for transfected adherent monkey kidney fibroblasts (COS-7) cells for electron microscopy studies, human osteosarcoma (U2OS) cells for super-resolution (SR) experiments and for hydrogels for scanning electron microscopy (SEM) studies.

General description

Glutaraldehyde is a fixative used in electron microscopy. It is a rapidly penetrating fixative and an alternative to the expensive and toxic buffered osmium tetroxide. Glutaraldehyde contains two aldehyde group separated by three methylene bridges. It mediates protein crosslinking at their amino groups.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

supp_hazards

EUH071

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
0000509556
0000509556
0000264267
0000249340
0000264267

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Biomaterials, 201(1), 99-112 (2019)
Formaldehyde, formalin, paraformaldehyde and glutaraldehyde: what they are and what they do
Kiernan JA
Microscopy today, 8(1), 8-13 (2000)
BRCA2 controls DNA: RNA hybrid level at DSBs by mediating RNase H2 recruitment
D?Alessandro G, et al.
Nature Communications, 9(1), 5376-5376 (2018)
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy
Schessl J, et al.
The Journal of Clinical Investigation, 118(3), 904-912 (2008)
Ming Fang et al.
BMC neuroscience, 16, 84-84 (2015-11-27)
Scutellarin, an anti-inflammatory agent, effectively suppressed microglia activation in rats with middle cerebral artery occlusion (MCAO). Robust microglia activation, acute in onset, was followed by astrogliosis. This study was aimed to determine if scutellarin would also affect the reactive astrocytes
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