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69478

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane

with 1% trimethylchlorosilane, for GC derivatization, LiChropur™

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About This Item

Empirical Formula (Hill Notation):
C6H12F3NOSi
CAS Number:
24589-78-4
Molecular Weight:
199.25
UNSPSC Code:
23151817
PubChem Substance ID:
329761687
NACRES:
NA.22
Beilstein/REAXYS Number:
1941550
MDL number:
MFCD00000411
Assay:
≥97.0%
Form:
liquid
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Product Name

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane, derivatization grade (GC derivatization), LiChropur™

grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥97.0%

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.378

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

General description

Silylation can be performed by adding N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MTFA) during analysis of fluorometabolites via gas chromatography-mass spectrometry (GC-MS).

Application

Addition of Trimethylchlorosilane aids in the derivatization of amides, secondary amines and hindered hydroxy groups. Most volatile of the TMS derivatives often elutes at the solvent front of the GC.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

78.8 °F - closed cup

flash_point_c

26 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6379
BCCL2549
BCCG9280
BCCJ5812
BCCF5955

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Applied Microbiology and Biotechnology, 97 (13), 5955-5963 (2013)
Harin Kanani et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 871(2), 191-201 (2008-06-10)
Metabolomics being the most recently introduced "omic" analytical platform is currently at its development phase. For the metabolomics to be broadly deployed to biological and clinical research and practice, issues regarding data validation and reproducibility need to be resolved. Gas
Iria González-Mariño et al.
Journal of chromatography. A, 1217(11), 1748-1760 (2010-02-13)
An alternative method for the sensitive determination of several drugs of abuse and some of their metabolites in surface and sewage water samples is proposed. Analytes are concentrated using a solid-phase extraction (SPE) sorbent, converted into the corresponding trimethylsilyl derivatives
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