118192
Rhodanine
97%
Synonym(s):
2-Thioxo-4-thiazolidinone
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About This Item
Empirical Formula (Hill Notation):
C3H3NOS2
CAS Number:
Molecular Weight:
133.19
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
205-505-1
Beilstein/REAXYS Number:
110701
MDL number:
Assay:
97%
Form:
solid
Product Name
Rhodanine, 97%
InChI key
KIWUVOGUEXMXSV-UHFFFAOYSA-N
InChI
1S/C3H3NOS2/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
SMILES string
O=C1CSC(=S)N1
assay
97%
form
solid
mp
165-169 °C (lit.)
solubility
methanol: soluble 2.5%, clear (yellow-green to orange-brown)
Quality Level
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Application
Rhodanine has been used in tannase assay in cultures of tannin degrading fungi.
Biochem/physiol Actions
Rhodanine inhibits the multiplication of echovirus 12 and the development of virus-induced morphologic changes.
General description
Rhodanine possess anticonvulsant, antibacterial, antiviral and antidiabetic activities.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Culture conditions for the production of a tannase of Aspergillus tamarii IMI388810 (B).
Enemuor SC and Odibo FJC.
African Journal of Biotechnology, 8(11), 2554-2557 (2009)
H J Eggers et al.
Science (New York, N.Y.), 167(3916), 294-297 (1970-01-16)
A search for compounds which have previously unrecognized antiviral activity led to the discovery that rhodanine inhibits the multiplication of echovirus 12 and also the development of virus-induced morphologic changes. Eighteen derivatives and analogs of rhodanine were synthesized and tested
Neil S Cutshall et al.
Bioorganic & medicinal chemistry letters, 15(14), 3374-3379 (2005-06-18)
Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this
Thomas Mendgen et al.
Journal of medicinal chemistry, 55(2), 743-753 (2011-11-15)
Rhodanines and related five-membered heterocycles with multiple heteroatoms have recently gained a reputation of being unselective compounds that appear as "frequent hitters" in screening campaigns and therefore have little value in drug discovery. However, this judgment appears to be based
N Hotta et al.
Diabetic medicine : a journal of the British Diabetic Association, 29(12), 1529-1533 (2012-04-18)
The goal of the study was to evaluate the efficacy of epalrestat, an aldose reductase inhibitor, on diabetic retinopathy and diabetic nephropathy, based on analysis of the results of the Aldose Reductase Inhibitor-Diabetes Complications Trial, a 3-year multicentre comparative clinical
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