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Merck

248509

(S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride solution

0.1 M in methylene chloride

Synonym(s):

(S)-(−)-N-(Trifluoroacetyl)prolyl chloride solution, TPC

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About This Item

Empirical Formula (Hill Notation):
C7H7ClF3NO2
CAS Number:
36724-68-2
Molecular Weight:
229.58
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
24854932
MDL number:
MFCD00010418
Beilstein/REAXYS Number:
480791

Key Documents

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optical purity

ee: 95% (GLC)

Quality Level

100

concentration

0.1 M in methylene chloride

refractive index

n20/D 1.424

density

1.308 g/mL at 25 °C

functional group

acyl chloride, fluoro

storage temp.

2-8°C

SMILES string

FC(F)(F)C(=O)N1CCC[C@H]1C(Cl)=O

InChI

1S/C7H7ClF3NO2/c8-5(13)4-2-1-3-12(4)6(14)7(9,10)11/h4H,1-3H2/t4-/m0/s1

InChI key

NUOYJPPISCCYDH-BYPYZUCNSA-N

Related Categories

Application

(S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride can be used as a chiral derivatization reagent:
  • In the chiral separation of psychoactive, cathinone- and amphetamine-related drugs using GC-MS technique.
  • In the estimation of cathinone related drug enantiomers in biological samples like urine and plasma using GC-MS technique.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

75-09-2

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX8194
MKCN9046
MKCN5801
MKCM0286
MKCL0669

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Luis M Valor et al.
PloS one, 12(8), e0183264-e0183264 (2017-08-18)
Plasma cells (PC) represent the heterogeneous final stage of the B cells (BC) differentiation process. To characterize the transition of BC into PC, transcriptomes from human naïve BC were compared to those of three functionally-different subsets of human in vivo-generated
Stefan Mohr et al.
Journal of chromatography. A, 1269, 352-359 (2012-10-13)
Since cathinone derivatives gained high popularity on the recreational drugs market within the past 5 years the development of analytical methods for the achiral and chiral determination of this substance class is of great interest. Not at least because it
Qiao Feng Tao et al.
Journal of biochemical and biophysical methods, 54(1-3), 103-113 (2003-01-25)
Several important chiral phenethylamine agents such as mexiletine, fenfluramine, amphetamine, methamphetamine and N-n-propylamphetamine show stereoselective disposition in humans and large differences in therapeutic relevance and toxicity. To analyze the enantiomers of chiral amine drugs, stereoselective methods were developed to separate
Simultaneous quantitative determination of synthetic cathinone enantiomers in urine and plasma using GC-NCI-MS
Alremeithi R, et al.
Journal of Analytical Methods in Chemistry, 2018 (2018)
Y Du et al.
European review for medical and pharmacological sciences, 23(15), 6570-6578 (2019-08-06)
Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy with physiological microRNA (miR) pathomorphological changes. MiR-548c-3p participates in multiple processes of tumor development and progression. However, the role of miR-548c-3p in PTC and the underlying mechanisms remain
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