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Merck

248924

7-Amino-4-(trifluoromethyl)coumarin

≥99%

Synonym(s):

Coumarin 151

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About This Item

Empirical Formula (Hill Notation):
C10H6F3NO2
CAS Number:
53518-15-3
Molecular Weight:
229.16
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
24854960
EC Number:
258-599-1
Beilstein/REAXYS Number:
4456797
MDL number:
MFCD00006858

Key Documents

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Product Name

7-Amino-4-(trifluoromethyl)coumarin, ≥99%

InChI key

JBNOVHJXQSHGRL-UHFFFAOYSA-N

InChI

1S/C10H6F3NO2/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4H,14H2

SMILES string

Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

assay

≥99%

form

(Powder or Crystals or Chunks)

technique(s)

titration: suitable

mp

221-222 °C (lit.)

λmax

≤207 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

100

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Related Categories

Application

Suitable as laser dye

General description

7-Amino-4-(trifluoromethyl)coumarin (AFC) is a novel fluorescent marker used for the detection of proteinases.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000325007
MKCV4735
MKCV9922
0000325007
MKCT1435

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E D Pederson et al.
Journal of clinical periodontology, 21(8), 519-525 (1994-09-01)
Treponema denticola (Td) and Porphyromonas gingivalis (Pg) are associated with human moderate and severe adult periodontal diseases. This study quantifies these two anaerobes and their trypsin-like (TL) activities in subgingival plaque collected from both clinically healthy and periodontally diseased sites
Synthesis and chemistry of 7-amino-4-(trifluoromethyl)coumarin and its amino acid and peptide derivatives
Bissell E R
The Journal of Organic Chemistry, 45, 2283?2287-2283?2287 (1980)
Takayasu Kawasaki et al.
Bioscience, biotechnology, and biochemistry, 76(4), 762-766 (2012-04-10)
Aggregations of proteins are in many cases associated with neurodegenerative diseases such as Alzheimer's (AD). Small compounds capable of inhibiting protein aggregation are expected to be useful for not only in the treatment of disease but also in probing the
Heike Helmbach et al.
The Journal of investigative dermatology, 118(6), 923-932 (2002-06-13)
Anticancer drugs kill susceptible cells through induction of apoptosis. Alterations of apoptotic pathways in drug-resistant tumor cells leading to apoptosis deficiency might represent a potent mechanism conferring drug resistance. We have assessed the effect of etoposide and cisplatin on the
S W Cox et al.
Journal of periodontal research, 24(6), 353-361 (1989-11-01)
Crevicular fluid samples were collected from 20 gingivitis and periodontitis patients using filter paper strips; these were then eluted into buffer. Portions of each sample were combined and the activities of this pooled eluate against different peptidyl derivatives of 7-amino-4-trifluoromethyl
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