363502
Poly[(R)-3-hydroxybutyric acid]
natural origin
Synonym(s):
(R)-3-Hydroxybutyric acid polymerized, PHB
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About This Item
Linear Formula:
[COCH2CH(CH3)O]n
CAS Number:
NACRES:
NA.23
PubChem Substance ID:
UNSPSC Code:
12162002
MDL number:
Product Name
Poly[(R)-3-hydroxybutyric acid], natural origin
InChI
1S/C12H20O6/c1-8(14)6-11(15)18-10(3)7-12(16)17-9(2)4-5-13/h5,8-10,14H,4,6-7H2,1-3H3
SMILES string
CC(O)CC(O)=O
InChI key
QLACRIKFZRFWRU-UHFFFAOYSA-N
transition temp
Tm 172 °C (DSC)
Quality Level
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Application
Poly[(R)-3-hydroxybutyric acid (PHB) is a biodegradable and biocompatible polymer produced by several bacterial species, owing to its low resorbability and tunable properties, it may find uses in a variety of applications such as tissue engineering, controlled release systems etc.
General description
Biocompatible, biodegradable polymer.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Molecular mass of poly [(R)-3-hydroxybutyric acid] produced in a recombinant Escherichia coli.
Kusaka S, et al.
Applied Microbiology and Biotechnology, 47(2), 140-143 (1997)
Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds.
Ricotti L, et al.
Biomedical Materials (Bristol, England), 7(3), 035010-035010 (2012)
Engineering of Saccharomyces cerevisiae for the production of poly-3-d-hydroxybutyrate from xylose.
Sandstrom A G, et al.
AMB Express, 5(1), 14-14 (2015)
Daniel Pfeiffer et al.
Journal of bacteriology, 194(21), 5909-5921 (2012-08-28)
Poly(3-hydroxybutyrate) (PHB) granules are covered by a surface layer consisting of mainly phasins and other PHB granule-associated proteins (PGAPs). Phasins are small amphiphilic proteins that determine the number and size of accumulated PHB granules. Five phasin proteins (PhaP1 to PhaP5)
Rui-Yan Wang et al.
PloS one, 8(3), e57943-e57943 (2013-03-14)
A couple of DNA ligation-independent cloning (LIC) methods have been reported to meet various requirements in metabolic engineering and synthetic biology. The principle of LIC is the assembly of multiple overlapping DNA fragments by single-stranded (ss) DNA overlaps annealing. Here
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