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Merck

708496

Acetyl chloride solution

1 M in methylene chloride

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About This Item

Empirical Formula (Hill Notation):
C2H3ClO
CAS Number:
75-36-5
Molecular Weight:
78.50
NACRES:
NA.22
PubChem Substance ID:
329762802
UNSPSC Code:
12352101
MDL number:
MFCD00000719
Form:
liquid

Key Documents

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InChI

1S/C2H3ClO/c1-2(3)4/h1H3

SMILES string

CC(Cl)=O

InChI key

WETWJCDKMRHUPV-UHFFFAOYSA-N

form

liquid

concentration

1 M in methylene chloride

refractive index

n20/D 1.423

density

1.294 g/mL at 25 °C

functional group

acyl chloride

Quality Level

100

Related Categories

Application

Acetyl chloride (AcCl) can be used as:
  • An acylating reagent to prepare useful key intermediates in organic synthesis.
  • A reagent to convert oxathioacetals and dithioacetals into corresponding carbonyl compounds in the presence of sodium nitrite.
  • An activating or acylating reagent in solid-phase organic synthesis.
  • A reagent to prepare various alkyl and aryl tetrahydropyranyl ethers from corresponding alcohols.

signalword

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3

target_organs

Central nervous system

wgk

WGK 2

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

75-09-2

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT8647
MKCL1414
MKCJ6496
MKCC7802
MKBX1975V

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A highly efficient procedure for regeneration of carbonyl groups from their corresponding oxathioacetals and dithioacetals using sodium nitrite and acetyl chloride in dichloromethane
Khan AT, et al.
Synlett, 2003(03), 0377-0381 (2003)
New phenylfluorenyl based linkers for solid phase synthesis
Bleicher KH, et al.
Tetrahedron Letters, 41(47), 9037-9042 (2000)
Selective synthesis of spirooxindoles via a two-step reaction of N-phenacylpyridinium bromide, 1, 3-indanedione and N-alkylisations
Sun J, et al.
Organic & Biomolecular Chemistry, 17(16), 3978-3983 (2019)
Solid phase synthesis of styrylquinazolinones
Theoclitou M-E, et al.
Tetrahedron Letters, 41(13), 2051-2054 (2000)
Acetyl chloride-mediated mild and chemoselective attachment and removal of tetrahydropyranyl (THP) group
Yeom C-E, et al.
Bulletin of the Korean Chemical Society,, 28(1), 103-107 (2007)
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