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Merck

79380

Phosgene solution

~20% in toluene

Synonym(s):

Carbon oxychloride, Carbonyl chloride, Phosgen

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About This Item

Linear Formula:
COCl2
CAS Number:
75-44-5
Molecular Weight:
98.92
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
57652789
MDL number:
MFCD00036119
Beilstein/REAXYS Number:
1098367
Form:
solution

Key Documents

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InChI

1S/CCl2O/c2-1(3)4

SMILES string

ClC(Cl)=O

InChI key

YGYAWVDWMABLBF-UHFFFAOYSA-N

form

solution

reaction suitability

reaction type: Carbonylations

concentration

~20% in toluene

impurities

≤300 mg/kg benzene

functional group

chloro

storage temp.

2-8°C

Quality Level

200

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General description

Phosgene is an organic chemical compound widely used as a chlorinating agent, carbonylating agent, and dehydrating agent in organic synthesis for the synthesis of various compounds.

Application

Phosgene solution (~20% in toluene) can be used as a reagent in the synthesis of multiblock copolymers via multiple coupling reactions. It is also used in the activation of the hydroxyl groups in poly(ethylene glycol) diol (PEG diol) to synthesize linear multifunctional poly(ethylene glycol).

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT SE 1 Inhalation - STOT SE 3

target_organs

Central nervous system, Lungs

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

39.2 °F - closed cup

flash_point_c

4 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

108-88-3

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP3899
BCCM6147
BCCK7819
BCCH0727
BCCJ7127

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Wenli Li et al.
Toxicological sciences : an official journal of the Society of Toxicology, 131(2), 612-628 (2012-11-13)
Phosgene gas is a lower respiratory tract irritant. As such, it stimulates nociceptive vagal C-fiber-related reflexes in a dose-rate and concentration × exposure duration (C × t)-dependent manner. In rats, this reflex is characterized by extended apnea time periods, bradycardia
Wen-Li Li et al.
Inhalation toxicology, 23(13), 842-852 (2011-11-01)
The principal acute mode of action of inhaled phosgene gas is related to an increase alveolar fluid exudation under pathologic conditions. This paper considers some aspects in modeling phosgene-induced acute lung injury (ALI) in an acute rat bioassay and whether
Hong-li Chen et al.
Journal of applied toxicology : JAT, 33(1), 71-77 (2011-08-06)
Phosgene is a poorly water-soluble gas penetrating the lower respiratory tract which can induce acute lung injury characterized by a latent phase of fatal pulmonary edema. Pulmonary edema caused by phosgene is believed to be a consequence of oxidative stress
Rui Liu et al.
Scientific reports, 2, 813-813 (2012-12-12)
Identifying a critical transition and its leading biomolecular network during the initiation and progression of a complex disease is a challenging task, but holds the key to early diagnosis and further elucidation of the essential mechanisms of disease deterioration at
Pradip Kundu et al.
Analytical chemistry, 84(10), 4594-4597 (2012-04-11)
Phosgene is a very toxic gas, which was used as a chemical weapon in World War I, and is currently widely used in industrial processes. So far, no any phosgene fluorescent sensor has been reported. In this study, we report
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