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Merck

79380

Phosgene solution

~20% in toluene

Synonym(s):

Carbon oxychloride, Carbonyl chloride, Phosgen

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About This Item

Linear Formula:
COCl2
CAS Number:
75-44-5
Molecular Weight:
98.92
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
57652789
MDL number:
MFCD00036119
Beilstein/REAXYS Number:
1098367

Product Name

Phosgene solution, ~20% in toluene

InChI

1S/CCl2O/c2-1(3)4

SMILES string

ClC(Cl)=O

InChI key

YGYAWVDWMABLBF-UHFFFAOYSA-N

form

solution

reaction suitability

reaction type: Carbonylations

concentration

~20% in toluene

impurities

≤300 mg/kg benzene

functional group

chloro

storage temp.

2-8°C

Quality Level

200

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Application

Phosgene solution (~20% in toluene) can be used as a reagent in the synthesis of multiblock copolymers via multiple coupling reactions. It is also used in the activation of the hydroxyl groups in poly(ethylene glycol) diol (PEG diol) to synthesize linear multifunctional poly(ethylene glycol).

General description

Phosgene is an organic chemical compound widely used as a chlorinating agent, carbonylating agent, and dehydrating agent in organic synthesis for the synthesis of various compounds.

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT SE 1 Inhalation - STOT SE 3

target_organs

Central nervous system, Lungs

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

39.2 °F - closed cup

flash_point_c

4 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM6147
BCCK7819
BCCH0727
BCCJ7127
BCCD0152

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Hong-li Chen et al.
Journal of applied toxicology : JAT, 33(1), 71-77 (2011-08-06)
Phosgene is a poorly water-soluble gas penetrating the lower respiratory tract which can induce acute lung injury characterized by a latent phase of fatal pulmonary edema. Pulmonary edema caused by phosgene is believed to be a consequence of oxidative stress
Wenli Li et al.
Toxicological sciences : an official journal of the Society of Toxicology, 131(2), 612-628 (2012-11-13)
Phosgene gas is a lower respiratory tract irritant. As such, it stimulates nociceptive vagal C-fiber-related reflexes in a dose-rate and concentration × exposure duration (C × t)-dependent manner. In rats, this reflex is characterized by extended apnea time periods, bradycardia
Wen-Li Li et al.
Inhalation toxicology, 23(13), 842-852 (2011-11-01)
The principal acute mode of action of inhaled phosgene gas is related to an increase alveolar fluid exudation under pathologic conditions. This paper considers some aspects in modeling phosgene-induced acute lung injury (ALI) in an acute rat bioassay and whether
J P Wyatt et al.
Journal of accident & emergency medicine, 12(3), 212-213 (1995-09-01)
Phosgene is a highly toxic gas to which some workers may be occupationally exposed. This case report demonstrates the possibility of refrigeration workers suffering phosgene poisoning after heating certain chlorinated fluorocarbons ('freons'). The need to suspect phosgene exposure and observe
O Gyllenhaal et al.
Journal of chromatography, 435(2), 259-269 (1988-01-08)
The use of phosgene as a derivatizing agent for bifunctional compounds prior to gas and liquid chromatographic analysis is reviewed. Applications include gas chromatographic determinations of metoprolol and its metabolites in biological fluids, enantiomeric separations of beta-blocking drugs and sympathomimetic
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