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Merck

L1002

L-Leucine methyl ester hydrochloride

98%, for peptide synthesis

Synonym(s):

(S)-2-Amino-4-methylpentanoic acid methyl ester hydrochloride, L-Leu-OMe·HCl

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NH2)COOCH3 · HCl
CAS Number:
7517-19-3
Molecular Weight:
181.66
NACRES:
NA.22
PubChem Substance ID:
24896269
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
231-375-0
MDL number:
MFCD00012494
Beilstein/REAXYS Number:
3595133

Key Documents

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Product Name

L-Leucine methyl ester hydrochloride, 98%

InChI

1S/C7H15NO2.ClH/c1-5(2)4-6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H/t6-;/m0./s1

InChI key

DODCBMODXGJOKD-RGMNGODLSA-N

SMILES string

Cl[H].COC(=O)[C@@H](N)CC(C)C

assay

98%

form

powder or crystals

optical activity

[α]22/D +13°, c = 2 in H2O

reaction suitability

reaction type: solution phase peptide synthesis

color

white

mp

151-153 °C (lit.)

application(s)

peptide synthesis

Quality Level

100

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ9340
MKCZ5766
MKCW9327
MKCV9227
MKCR5249

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Stephanie M Krasnow et al.
Journal of neuroinflammation, 14(1), 133-133 (2017-07-03)
During acute infections and chronic illnesses, the pro-inflammatory cytokine interleukin-1β (IL-1β) acts within the brain to elicit metabolic derangements and sickness behaviors. It is unknown which cells in the brain are the proximal targets for IL-1β with respect to the
T Kiyomasu et al.
Immunology letters, 69(2), 239-245 (1999-09-11)
Recently, long-term preculture with IL-4 or IL-7 has been reported to induce IFN-gamma-producing ability in naive CD4+ T cells without stimulation via TCR. The mechanism of IFN-gamma-transcription in naive CD4+ T cells precultured with IL-4 was analyzed and compared with
P Parenti et al.
Insect biochemistry and molecular biology, 32(7), 719-727 (2002-06-05)
We have identified three methyl esters that have a potent stimulatory effect on the cotransport system responsible for the absorption of most essential amino acids in the silkworm Bombyx mori. L-Leucine methyl ester, the most powerful activator, determined a large
A Giese et al.
Brain pathology (Zurich, Switzerland), 8(3), 449-457 (1998-07-21)
To elucidate the role played by the prion protein in scrapie pathogenesis, we performed experiments with PrP27-30 isolated from scrapie-infected hamster brains in cell culture and studied in vivo the temporal and spatial correlation between deposition of the disease-associated isoform
Gautam K Gandhi et al.
ASN neuro, 2(2), e00030-e00030 (2010-04-17)
Sensory and cognitive impairments have been documented in diabetic humans and animals, but the pathophysiology of diabetes in the central nervous system is poorly understood. Because a high glucose level disrupts gap junctional communication in various cell types and astrocytes
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