260684
1-Deoxynojirimycin, Hydrochloride - CAS 73285-50-4 - Calbiochem
A specific glucosidase inhibitor including trimming glucosidases I and II, enzymes that sequentially remove the three glucose residues from precursor Glc3Man9-GlcNAc2 in N-linked glycan biosynthesis.
Synonym(s):
1-Deoxynojirimycin, Hydrochloride - CAS 73285-50-4 - Calbiochem, DNJ, HCl
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About This Item
Empirical Formula (Hill Notation):
C6H13NO4 · xHCl
CAS Number:
Molecular Weight:
163.17 (free base basis)
UNSPSC Code:
12352200
MDL number:
assay
≥98% (TLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
solubility
water: 100 mM
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
Glucosidase 1, glucosidase 2
Glucosidase 1, glucosidase 2
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Irritant (B)
General description
A specific glucosidase inhibitor including trimming glucosidases I and II, enzymes that sequentially remove the three glucose residues from precursor Glc3Man9-GlcNAc2 in N-linked glycan biosynthesis.
Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc3Man9GlcNAc2 in N-linked glycan biosynthesis.
Other Notes
Suh, K., et al. 1992. J. Biol. Chem. 267, 21671.
Fuhrmann, U., et al. 1985. Biochim. Biophys. Acta825, 95.
Fuhrmann, U., et al. 1985. Biochim. Biophys. Acta825, 95.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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K Suh et al.
The Journal of biological chemistry, 267(30), 21671-21677 (1992-10-25)
The role of glucosylated oligosaccharides in the biogenesis of the glycoprotein (G protein) of vesicular stomatitis virus was studied in PhaR2.7, a mouse lymphoma cell line deficient in glucosidase II activity. As expected, the great majority of cell-associated G protein
Inhibitors of oligosaccharide processing.
U Fuhrmann et al.
Biochimica et biophysica acta, 825(2), 95-110 (1985-06-24)
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