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Merck

344150

FPT Inhibitor I

The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

FPT Inhibitor I

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About This Item

Empirical Formula (Hill Notation):
C19H29NO6P · 3Na
Molecular Weight:
467.38
UNSPSC Code:
12352200
Assay:
≥85% (NMR)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
desiccated (hygroscopic)

Key Documents

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Product Name

FPT Inhibitor I, The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

assay

≥85% (NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: ≥10 mg/mL

shipped in

ambient

storage temp.

−70°C

Quality Level

100

Biochem/physiol Actions

Primary Target
Farnesyltransferase (Ftase)
Product does not compete with ATP.
Target IC50: 83 nM against Ftase

Disclaimer

Toxicity: Standard Handling (A)

General description

A highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 83 nM). Inhibits geranylgeranyltransferase I (IC50 = 26 µM) and II (IC50 = 47 µM) at much higher concentrations.
Potent and highly selective inhibitor of farnesyltransferase (FTase; IC50 = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC50 = 26 µM and 47 µM for GGTase I and II, respectively).
The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

Other Notes

Manne, V., et al. 1995. Drug Development Res.34, 121.
Patel, D.V., et al. 1995. J. Med. Chem.38, 2906.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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