526522
PIM1 Kinase Inhibitor IV
The PIM1 Kinase Inhibitor IV, also referenced under CAS 477845-12-8, controls the biological activity of PIM1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
PIM1 Kinase Inhibitor IV, 4-(3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl)-2-pyrimidinamine
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About This Item
Empirical Formula (Hill Notation):
C17H11ClN4O
CAS Number:
Molecular Weight:
322.75
UNSPSC Code:
12352200
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Disclaimer
Toxicity: Standard Handling (A)
General description
A pyrimidinyl-benzisoxazolo compound that interacts with Lys67 and Glu121 at the PIM1 active site and inhibits PIM1 kinase activity with a Ki value of 0.091 µM.
Other Notes
Pierce, A.C., et al. 2008. J. Med. Chem.51, 1972.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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Albert C Pierce et al.
Journal of medicinal chemistry, 51(6), 1972-1975 (2008-02-23)
To supplement the hits from a high throughput screen, docking was performed against Pim-1 kinase. Glide docking was augmented with a filter to require traditional or aromatic CH..O hydrogen bonds to the kinase hinge. Four diverse actives, of 96 molecules
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