HAIAB-10K
MILLIPLEX® Human Autoimmune Autoantibody Panel 20-Plex
Milliplex®, Configurable Human Autoimmune Autoantibody IgG 20-Plex Panel
Synonym(s):
ANA multiplex kit, IgG autoantibody profiling, Luminex® autoimmune serology assay
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000
Product Name
MILLIPLEX® Human Autoimmune Autoantibody Panel 20-Plex, Milliplex®, Configurable Human Autoimmune Autoantibody IgG 20-Plex Panel
manufacturer/tradename
Milliplex®
species reactivity
human
packaging
pkg of 1 ea
technique(s)
multiplexing: suitable
input
serum plasma
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
Features and Benefits
- Comprehensive Autoantibody Profiling: Detects 20 relevant autoantibodies associated with a wide spectrum of autoimmune diseases, including lupus, Sjögren′s Syndrome, systemic sclerosis, and MCTD.
- Qualitative Multiplex Assay Format: Designed for qualitative detection, allowing researchers to assess the presence or absense of autoantibodies in a single run.
- Built-In Assay Controls: Includes four assay control beads in the base kit to ensure assay integrity.
- Configurable Panel Design: Select specific analytes from the panel to tailor the assay to your study needs, enhancing flexibility and cost-efficiency.
- Supports Autoimmune Disease Research: Enables detection of autoantibodies that are associated with disease activity and overlap syndromes, supporting mechanistic studies.
General description
Autoantibody formation is principal to the pathogenesis of a variety of autoimmune diseases. Dysregulated apoptosis and the subsequent defective clearance of cellular debris leads to the exposure of autoantigens and the generation of autoantibodies. The presence of autoantibodies may indicate disease activity, prognosis, and clinical associations related to a variety of autoimmune diseases. These autoimmune diseases include, but are not limited to, Sjögren′s Syndrome, Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, Systemic Sclerosis, CREST syndrome, Polymyositis/Dermatomyositis, Vasculitis, Anti-Phospholipid Syndrome, and various overlap syndromes of these diseases.
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 20 analytes in human serum and plasma samples.
Analytes included: β2-Glycoprotein, C1q, CENP-B (Centromere Protein B), CENP-A (Centromere Protein A), Jo-1, Ku, Mi-2, Myeloperoxidase (MPO), PCNA (Proliferating Cell Nuclear Antigen A), PL-12 (Alanyl-tRNA synthetase), PM/Scl 100, Proteinase 3, RNP (Ribonucleoprotein), RNP/Smith (RNP/Sm), Ribosomal P, Scl-70, Sm, SSB/La (Sjögren′s Syndrome-related antigen B/La), SSA/Ro60 (Sjögren′s Syndrome-related antigen A/Ro60 kDa), SSA/Ro52 (Sjögren′s Syndrome-related antigen A/Ro52 kDa)
Note: This is a qualitative assay.Assay Characteristics: Refer to kit protocol for assay cross-reactivity and precision.
Analytes included: β2-Glycoprotein, C1q, CENP-B (Centromere Protein B), CENP-A (Centromere Protein A), Jo-1, Ku, Mi-2, Myeloperoxidase (MPO), PCNA (Proliferating Cell Nuclear Antigen A), PL-12 (Alanyl-tRNA synthetase), PM/Scl 100, Proteinase 3, RNP (Ribonucleoprotein), RNP/Smith (RNP/Sm), Ribosomal P, Scl-70, Sm, SSB/La (Sjögren′s Syndrome-related antigen B/La), SSA/Ro60 (Sjögren′s Syndrome-related antigen A/Ro60 kDa), SSA/Ro52 (Sjögren′s Syndrome-related antigen A/Ro52 kDa)
Note: This is a qualitative assay.Assay Characteristics: Refer to kit protocol for assay cross-reactivity and precision.
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
Storage Class
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
wgk
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Dan Li et al.
JCI insight, 5(2) (2019-12-27)
Genetic variants within or near the interferon regulatory factor 5 (IRF5) locus associate with systemic lupus erythematosus (SLE) across ancestral groups. The major IRF5-SLE risk haplotype is common across populations, yet immune functions for the risk haplotype are undefined. We
Jieun Kwon et al.
The ocular surface, 18(1), 80-97 (2019-10-14)
To investigate the role of Anti-Citrullinated Protein autoantibodies (ACPAs) in the pathology of dry eye disease (DED) and the therapeutic potential of pooled human immune globulin-eye drops in these patients. We investigated the presence of citrullinated proteins and ACPAs in
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