Skip to Content
Merck

14690

Bis(cyclohexanone)oxaldihydrazone

for spectrophotometric det. of Cu, ≥99.0%

Synonym(s):

Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide)

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C14H22N4O2
CAS Number:
370-81-0
Molecular Weight:
278.35
UNSPSC Code:
41116105
NACRES:
NA.21
PubChem Substance ID:
329750579
EC Number:
206-729-2
Beilstein/REAXYS Number:
2388004
MDL number:
MFCD00001659

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

DSRJIHMZAQEUJV-UHFFFAOYSA-N

InChI

1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)

SMILES string

O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2

assay

≥99.0% (N), ≥99.0%

form

powder

quality

for spectrophotometric det. of Cu

technique(s)

UV/Vis spectroscopy: suitable

mp

210-214 °C (lit.), 210-214 °C

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

Cuprizone (Bis(cyclohexanone)oxaldihydrazone) was used for toxic demyelination in the central nervous system in order to investigate the pathobiology of remyelination in the corpus callosum, so as to study the human demyelinating diseases such as multiple sclerosis. It was also used a model to study components of neuroinflammation.

General description

Cuprizone (Bis(cyclohexanone)oxaldihydrazone) is a physically unstable compound and is a well-known neurotoxic agent.

Other Notes

For the spectrophotometric determination of Cu(II)
In the presence of a copper salt, this ligand catalyzes Ullmann-type C-N bond forming reactions under mild, aqueous conditions.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCN8269
BCCM8365
BCCL6012
BCCL0172
BCCK4085

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Zhu, X., et al.
Synthesis, 23, 3955-3962 (2006)
Cuprizone treatment induces distinct demyelination, astrocytosis, and microglia cell invasion or proliferation in the mouse cerebellum.
Groebe A
Cerebellum, 8 (3), 163-174 (2009)
Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent.
Thomas S
The American Journal of Pathology, 174 (4), 1053-1061 (2008)
R.K. Rohde
Analytical Chemistry, 38, 911-911 (1966)
The protective role of nitric oxide in a neurotoxicant-induced demyelinating model.
Arnett H
Journal of Immunology, 168 (1), 427-433 (2002)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service