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Merck

46656

Prednisolone

VETRANAL®, analytical standard

Synonym(s):

1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrocortisol, 1-Dehydrohydrocortisone, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C21H28O5
CAS Number:
50-24-8
Molecular Weight:
360.44
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329756614
EC Number:
200-021-7
Beilstein/REAXYS Number:
1354103
MDL number:
MFCD00003649

Product Name

Prednisolone, VETRANAL®, analytical standard

InChI key

OIGNJSKKLXVSLS-VWUMJDOOSA-N

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

SMILES string

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

240 °C (dec.) (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

Gene Information

human ... NR3C1(2908)

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Application

Prednisolone may be used as an analytical standard for the determination of prednisolone in:
  • Human plasma by multivariate curve resolution-alternating least squares (MCR-ALS) technique combined with high performance liquid chromatography-diode array detection (HPLC-DAD).
  • Urine, blood and food matrices by solid-phase extraction (SPE) and LC coupled to tandem mass spectrometry (LC-MS/MS).
  • Surface water samples by SPE and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF) with electrospray ionization (ESI).
  • Bovine muscle samples by ESI-LC-MS/MS equipped with multiple reaction monitoring (MRM) detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Prednisolone is classified under the corticosteroids class of compounds.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG7680
BCBW5950

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Quantification of doping compounds in faecal samples from racing pigeons, by liquid chromatography-tandem mass spectrometry.
Moreira FX, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1089, 33-42 (2018)
Handling of highly coeluted chromatographic peaks by multivariate curve resolution for a complex bioanalytical problem: Quantitation of selected corticosteroids and mycophenolic acid in human plasma.
Rezaei F, et al.
Talanta, 187, 1-12 (2018)
Database-driven screening of South African surface water and the targeted detection of pharmaceuticals using liquid chromatography-High resolution mass spectrometry.
Wood TP, et al.
Environmental Pollution (Barking, Essex : 1987), 230, 453-462 (2017)
Ádám Tölgyesi et al.
Journal of pharmaceutical and biomedical analysis, 145, 805-813 (2017-08-20)
Veterinary drugs containing synthetic anabolic steroid and nitroimidazole active agents are not allowed for their applications in livestock of the European Union (EU). This paper presents analyses of twelve selected steroids and six nitroimidazole antibiotics at low levels (1.56μg/L-4.95μg/L and
Simultaneous determination of residues of non-steroidal anti-inflammatory drugs and glucocorticosteroids in animal muscle by liquid chromatography-tandem mass spectrometry.
Jedziniak P, et al.
Food Analytical Methods, 9(6), 1837-1848 (2016)
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