A0231
AS 604850
≥98% (HPLC), solid
Synonym(s):
5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI3Kγ inhibitor
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C11H5F2NO4S
CAS Number:
Molecular Weight:
285.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Product Name
AS 604850, ≥98% (HPLC), solid
InChI key
SRLVNYDXMUGOFI-YWEYNIOJSA-N
SMILES string
FC1(F)Oc2ccc(cc2O1)\C=C3/SC(=O)NC3=O
InChI
1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: >10 mg/mL
H2O: <2 mg/mL
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
AS 604850 is a selective PI3Kγ inhibitor
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Daniela Kovacs et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6302-6321 (2020-03-12)
Bovine colostrum, the first milk secreted by the mammary glands of cows shortly after they have given birth, provides a natural source of bioactive substances helpful to promote tissue development and repair, and to maintain a healthy immune system. Owing
Montserrat Camps et al.
Nature medicine, 11(9), 936-943 (2005-08-30)
Phosphoinositide 3-kinases (PI3K) have long been considered promising drug targets for the treatment of inflammatory and autoimmune disorders as well as cancer and cardiovascular diseases. But the lack of specificity, isoform selectivity and poor biopharmaceutical profile of PI3K inhibitors have
Chatvadee Kornsuthisopon et al.
Scientific reports, 14(1), 6777-6777 (2024-03-22)
Extracellular matrix (ECM) is an intricate structure providing the microenvironment niche that influences stem cell differentiation. This study aimed to investigate the efficacy of decellularized ECM derived from human dental pulp stem cells (dECM_DPSCs) and gingival-derived mesenchymal stem cells (dECM_GSCs)
Hon Yan K Yip et al.
Molecular cell, 80(2), 279-295 (2020-10-17)
The PTEN tumor suppressor controls cell death and survival by regulating functions of various molecular targets. While the role of PTEN lipid-phosphatase activity on PtdIns(3,4,5)P3 and inhibition of PI3K pathway is well characterized, the biological relevance of PTEN protein-phosphatase activity
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service