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Merck

A9434

Ammonium chloride

Molecular Biology, suitable for cell culture, ≥99.5%

Synonym(s):

Salmiac

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About This Item

Linear Formula:
NH4Cl
CAS Number:
12125-02-9
Molecular Weight:
53.49
NACRES:
NA.31
PubChem Substance ID:
24891452
eCl@ss:
38050207
UNSPSC Code:
12352302
EC Number:
235-186-4
MDL number:
MFCD00011420
Beilstein/REAXYS Number:
4371014
Assay:
≥99.5%
Grade:
Molecular Biology
Form:
powder or crystals

Key Documents

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Product Name

Ammonium chloride, Molecular Biology, suitable for cell culture, ≥99.5%

InChI key

NLXLAEXVIDQMFP-UHFFFAOYSA-N

InChI

1S/ClH.H3N/h1H;1H3

SMILES string

N.Cl

grade

Molecular Biology

vapor density

1.9 (vs air)

vapor pressure

1 mmHg ( 160.4 °C)

assay

≥99.5%

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

mp

340 °C (subl.) (lit.)

anion traces

phosphate (PO43-): ≤2 ppm
sulfate (SO42-): ≤20 ppm

cation traces

Fe: ≤2 ppm
heavy metals (as Pb): ≤5 ppm

foreign activity

DNase, RNase, protease, none detected

Quality Level

200

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Application

Ammonium chloride has been used:
  • as an inhibitor of endosome acidification in vero cells
  • as an autophagy inhibitor in vascular smooth muscle cell (VSMC)
  • in the depletion and lysis of erythrocytes in testis parenchyma homogenate

Biochem/physiol Actions

Ammonium chloride is one of the three principal components of the nitrogen cycle. Ammonium chloride administration promotes creatinine and urea clearance andinduces metabolic acidosis in mice. Excess of ammonium chloride inhibits Kreb′s pathway in brain and depletes ATP in astrocytes. Ammonium chloride inhibits acidification in the endosome-lysosome system. Ammonium chloride is a hemolysing agent used for the lysis of erythrocytes.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

12125-02-9

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
0000456277
0000456277
0000431159
0000431158
0000431158

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Aqueous ammonia and ammonium chloride hydrates: Principal infrared spectra
Max JJ and Chapados C
Journal of Molecular Structure, 1046, 124-135 (2013)
Effect of ammonium chloride and dietary phosphorus in the azotaemic rat. I. Renal function and biochemical changes
Jara A, et al.
Nephrology, Dialysis, and Transplantation, 19(8), 1986-1992 (2004)
Infectious bronchitis virus entry mainly depends on clathrin mediated endocytosis and requires classical endosomal/lysosomal system
Wang H, et al.
Virology, 528, 118-136 (2019)
Erythrocyte lysis in isotonic solution of ammonium chloride: Theoretical modeling and experimental verification
Chernyshev AV, et al.
Journal of Theoretical Biology, 251(1), 93-107 (2008)
Nrf2 Activation Provides Atheroprotection in Diabetic Mice Through Concerted Upregulation of Antioxidant, Anti-inflammatory, and Autophagy Mechanisms
Lazaro I, et al.
Frontiers in Pharmacology, 9, 118-136 (2018)
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