C5259
Carbamyl-β-methylcholine chloride
≥99% (TLC), crystalline
Synonym(s):
Bethanechol chloride
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About This Item
Linear Formula:
C7H17N2O2Cl
CAS Number:
Molecular Weight:
196.68
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
209-686-8
MDL number:
InChI key
AIRHOJQHGLTTTB-UHFFFAOYSA-N
InChI
1S/C7H17N2O2.ClH/c1-6(11-7(8)10)5-9(2,3)4;/h6H,5H2,1-4H3,(H2,8,10);1H
SMILES string
Cl.CC(C[N](C)(C)C)OC(N)=O
assay
≥99% (TLC)
form
crystalline
color
white
solubility
H2O: 1.7 g/mL (stable for several days at 4°C.), ethanol: 80 mg/mL (stable for several days at 4°C.)
storage temp.
2-8°C
Quality Level
General description
Muscarinic acetylcholine receptor agonist that is not a substrate for acetylcholinesterase.
Application
Carbamyl-β-methylcholine chloride has been used in western blotting and bactericidal assay. It has also been used in concentration-response studies with isolated atrial preparation.
Biochem/physiol Actions
Carbamyl-β-methylcholine has a selective action on urinary bladder and intestine. It induces smooth muscle tension in the bladder. Its main function is to induce detrusor muscle action, mediated by postganglionic parasympathetic effector cells. Nausea, flushing, sweating, abdominal cramps are some of the side effect caused by carbamyl-β-methylcholine.
Disclaimer
Hygroscopic.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Equine Internal Medicine, 1227-1227 (2009)
Generation of a human urinary bladder smooth muscle cell line.
Zheng Y, Chang S, Boopathi E, et al.
In Vitro Cellular & Developmental Biology, 48, 84-96 (2012)
Y Koga et al.
European journal of pharmacology, 220(2-3), 141-146 (1992-09-22)
To seek evidence for the involvement of acetylcholinesterase activity in the modulatory influence of the airway epithelium, we examined responses to acetylcholine (ACh), bethanechol, histamine or KCl in isolated epithelium-intact and epithelium-denuded guinea-pig trachealis preparations. The concentration-response curves to ACh
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In the present study we examined whether histamine H(4) receptors (H(4)Rs) have a role in gastric ulcerogenesis using a mouse model of gastric damage. The H(4)R antagonist JNJ7777120 and the H(4)R agonists VUF8430 and VUF10460 were investigated in fasted CD-1
Darryl J Adamko et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 14(5), 321-327 (2012-05-23)
Diagnosing asthma in infancy is largely made on the basis of the symptoms of cough and wheezing. A similar presentation can be seen in neurologically normal infants with excessive gastroesophageal reflux (GER). There are no randomized placebo controlled studies in
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