N9876

4-Nitrophenyl butyrate

Name: 4-Nitrophenyl butyrate
Brand: SIGMA

lipase substrate, chromogenic, esterase substrate, ≥98%, liquid

Synonym(s):

p-Nitrophenyl butyrate, Butyric acid 4-nitrophenyl ester

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₁NO₄

CAS Number:

2635-84-9

Molecular Weight:

209.20

NACRES:

NA.83

PubChem Substance ID:

24897915

UNSPSC Code:

12352204

MDL number:

MFCD00047734

Beilstein/REAXYS Number:

1879729

Product Name

4-Nitrophenyl butyrate, ≥98%

InChI

1S/C10H11NO4/c1-2-3-10(12)15-9-6-4-8(5-7-9)11(13)14/h4-7H,2-3H2,1H3

SMILES string

CCCC(=O)Oc1ccc(cc1)[N+]([O-])=O

InChI key

DVDUMIQZEUTAGK-UHFFFAOYSA-N

assay

≥98%

form

liquid

density

1.19 g/mL at 20 °C (lit.)

storage temp.

−20°C

Quality Level

200

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Application

4-nitrophenyl butyrate has been used:

as a substrate for esterase activity in monocyte-derived macrophage cell line in response to polyethylene
as a substrate for mycobacterial phospholipase A and mycobacterial cutinase activity
as a substrate to determine the effect of buffers and solvents on human carboxylesterase

General description

4-Nitrophenyl butyrate is a substrate for esterase, and lipase enzyme. Hydrolysis of 4-nitrophenyl butyrate by these enzymes releases the chromophore, 4-nitrophenolate which is spectrophotometrically analysed at 415 nm.

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Lactic acid bacteria-fermented product of green tea and Houttuynia cordata leaves exerts anti-adipogenic and anti-obesity effects.

Li-Chun Wang et al.

Journal of food and drug analysis, 26(3), 973-984 (2018-07-07)

Obesity is associated with higher risks of developing diabetes and cardiovascular disease. Green tea, rich in polyphenolic compounds such as epigallocatechin gallate (EGCG) and epigallocatechin (EGC), has been shown to display anti-obesity effects. Houttuynia cordata leaves have also been shown

Immobilization of lipase from Pseudomonas fluorescens on glyoxyl-octyl-agarose beads: Improved stability and reusability.

Nathalia S Rios et al.

Biochimica et biophysica acta. Proteins and proteomics, 1867(9), 741-747 (2019-06-16)

The lipase from Pseudomonas fluorescens (PFL) has been immobilized on glyoxyl-octyl agarose and compared to the enzyme immobilized on octyl-agarose. Thus, PFL was immobilized at pH 7 on glyoxyl-octyl support via lipase interfacial activation and later incubated at pH 10.5 for 20 h

Monitoring lipase/esterase activity by stopped flow in a sequential injection analysis system using p-nitrophenyl butyrate

Pliego J, et al.

Sensors, 15(2), 2798-2811 (2015)

Lipase and esterase: to what extent can this classification be applied accurately?

Lopes DB, et al.

Food Sci. Technol., 31(3), 603-613 (2011)

Mycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatin.

Sarah K Parker et al.

PloS one, 4(1), e4281-e4281 (2009-01-27)

The cell wall of M. tuberculosis is central to its success as a pathogen. Mycolic acids are key components of this cell wall. The genes involved in joining the alpha and mero mycolates are located in a cluster, beginning with

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