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Merck

P7877

6-Phosphogluconic acid trisodium salt

≥97% (enzymatic)

Synonym(s):

D-Gluconate 6-phosphate trisodium salt

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About This Item

Empirical Formula (Hill Notation):
C6H10Na3O10P
CAS Number:
53411-70-4
Molecular Weight:
342.08
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24898882
EC Number:
258-543-6
Beilstein/REAXYS Number:
3814212
MDL number:
MFCD00083681

Product Name

6-Phosphogluconic acid trisodium salt, ≥97% (enzymatic)

InChI key

CBQSOSFCUWVWAQ-CXKLNRRHSA-K

InChI

1S/C6H13O10P.3Na/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12;;;/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15);;;/q;3*+1/p-3/t2-,3-,4+,5-;;;/m1.../s1

SMILES string

[Na+].[Na+].[Na+].O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

biological source

synthetic (organic)

assay

≥97% (enzymatic)

form

powder

impurities

<0.05 mol % glucose-6-phosphate

color

light yellow

solubility

water: 50 mg/mL, clear, colorless

cation traces

Na: 18.8-21.5% (dry basis)

application(s)

agriculture

storage temp.

−20°C

Quality Level

200

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Application

6-Phosphogluconic acid has been used in a study to assess a spectrophotometric method for the determination of creative phosphokinase and myokinase. It has also been used in a study to investigate the reversible enzymatic sythesis of diphosphopyridine nucleotide and inorganic pyrophosphate.

Biochem/physiol Actions

Phosphogluconic acid is an intermediate in the pentose phosphate pathway.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Preparation Note

Prepared by a modification of the procedure of Seegmiller, J.E., et al., J. Biol. Chem., 192, 175 (1951).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000473527
0000473521
0000473519
0000473519
0000473521

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Reversible enzymatic sythesis of diphosphopyridine nucleotide and inorganic pyrophosphate
Kornberg, A.
The Journal of Biological Chemistry, 182, 779-793 (1950)
A spectrophotometric method for the determination of creatine phosphokinase and myokinase.
I T OLIVER
The Biochemical journal, 61(1), 116-122 (1955-09-01)
Yasaman Barekatain et al.
Communications biology, 3(1), 328-328 (2020-06-27)
Magnetic resonance (MR) spectroscopy has potential to non-invasively detect metabolites of diagnostic significance for precision oncology. Yet, many metabolites have similar chemical shifts, yielding highly convoluted 1H spectra of intact biological material and limiting diagnostic utility. Here, we show that
Ruilong Liu et al.
Nature communications, 10(1), 991-991 (2019-03-03)
6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles

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