P9511
3-sn-Phosphatidic acid sodium salt from egg yolk lecithin
≥98%, Phosphatidic acid precursor, powder
Synonym(s):
1,2-Diacyl-sn-glycero-3-phosphate sodium salt, L-α-Phosphatidic acid sodium salt, PA
Product Name
3-sn-Phosphatidic acid sodium salt from egg yolk lecithin, ≥98%
SMILES string
[Na+].[Na+].OC[C@@H](O)COP([O-])([O-])=O
InChI key
GEKBIENFFVFKRG-HWYNEVGZSA-L
InChI
1S/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;/q;2*+1/p-2/t3-;;/m1../s1
assay
≥98%
form
powder
storage temp.
−20°C
Quality Level
Related Categories
General description
Phosphatidic acid is obtained from phosphatidylcholine with the help of phospholipase D.
Application
3-sn-Phosphatidic acid sodium salt from egg yolk lecithin
- in the reaction mixture for CDS (cytidine triphosphate:phosphatidate cytidyltransferase) assay and reference lipid for thin layer chromatography (TLC)
- as a standard to compare the generated radiolabeled phosphatidic acid (PA)
- to examine its effects on At-Rac2–associated kinase activity
Biochem/physiol Actions
Phosphatidic acid might serve as a modulator of phagocyte respiratory burst. It also acts as a precursor of diacylglycerol, phosphatidic acid and lysophosphatidic acid.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases, Phosphoinositide Kinases and Phosphoprotein Phosphatases (Serine/Threonine) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Prepared from L-α-phosphatidylcholine by hydrolysis with cabbage phospholipase D.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Complementary DNAs encoding eukaryotic-type cytidine-5 [prime]-diphosphate-diacylglycerol synthases of two plant species
Kopka J, et al.
Plant Physiology, 113(3), 997-1002 (1997)
Daniel Pastor-Flores et al.
Biochimica et biophysica acta, 1861(3), 249-259 (2016-01-09)
Pkh is the yeast ortholog of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1). Pkh phosphorylates the activation loop of Ypks, Tpks, Sch9 and also phosphorylates the eisosome components Lsp1 and Pil1, which play fundamental roles upstream of diverse signaling pathways
Glycerolipids in signal transduction
Lambeth JD, et al.
New Biotechnology, 31, 237-255 (1996)
Rac homologues and compartmentalized phosphatidylinositol 4, 5-bisphosphate act in a common pathway to regulate polar pollen tube growth
Kost B, et al.
The Journal of cell biology, 145(2), 317-330 (1999)
Stefano Mancuso et al.
Plant signaling & behavior, 2(4), 240-244 (2007-07-01)
Auxin (IAA) is versatile signalling molecule of plants, currently classified as plant hormone. But there are data suggesting that auxin is acting also as plant-specific morphogen, electric-responses inducing transmitter, and as general signalling molecule used for plant-bacteria communication. Our previous
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