R3030

Risperidone

Name: Risperidone
Brand: SIGMA

≥98% (HPLC), powder, antipsychotic

Synonym(s):

R 64,766

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₇FN₄O₂

CAS Number:

106266-06-2

Molecular Weight:

410.48

UNSPSC Code:

12352200

PubChem Substance ID:

329824020

NACRES:

NA.77

MDL number:

MFCD00274576

Product Name

Risperidone, ≥98% (HPLC), powder

form

powder

color

white to off-white

SMILES string

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1

InChI key

RAPZEAPATHNIPO-UHFFFAOYSA-N

InChI

1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

assay

≥98% (HPLC)

solubility

DMSO: ≥5 mg/mL

originator

Johnson & Johnson

storage temp.

room temp

Quality Level

100

Gene Information

human ... DRD2(1813), HTR2A(3356), HTR2C(3358)

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Bioactive Small Molecules

Application

Risperidone has been used:

to study its effects on bone formation and differentiation
to investigate the relationship between risperidone (RIS) dosages and RIS plasma levels in autism spectrum disorder (ASD) pediatric patients
to reverse induced schizophrenia-like behavior in mice

Biochem/physiol Actions

Risperidone is an antipsychotic; serotonin-dopamine antagonist.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Risperidone is a benzisoxazole derivative. It functions as an antagonist for dopamine D₂, histamine H₁ and α₁ and α₂ adrenergic receptors. Risperidone is used to treat schizophrenia, bipolar disorder and autism.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Overexpression of transmembrane protein 168 in the mouse nucleus accumbens induces anxiety and sensorimotor gating deficit

Fu K, et al.

PLoS ONE, 12(12), e0189006-e0189006 (2017)

Schizophrenia (2006)

Development and validation of liquid chromatography/tandem mass spectrometry analysis for therapeutic drug monitoring of risperidone and 9-hydroxyrisperidone in pediatric patients with autism spectrum disorders

Vanwong N, et al.

Journal of Clinical Laboratory Analysis, 30(6), 1236-1246 (2016)

Effect of risperidone on proliferation and apoptosis of MC3T3-E1 cells

Zheng L, et al.

Brazilian journal of medical and biological research, 52(3) (2019)

Kaplan & Sadock's Concise Textbook of Clinical Psychiatry (2008)

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