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Merck

S6635

Span® 20

greener alternative

Synonym(s):

Sorbitan laurate, Sorbitan monolaurate

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About This Item

CAS Number:
1338-39-2
NACRES:
NA.25
PubChem Substance ID:
24899716
UNSPSC Code:
12161900
EC Number:
215-663-3
MDL number:
MFCD00005365

Key Documents

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InChI key

LWZFANDGMFTDAV-WYDSMHRWSA-N

InChI

1S/C18H34O6/c1-2-3-4-5-6-7-8-9-10-11-16(21)23-13-15(20)18-17(22)14(19)12-24-18/h14-15,17-20,22H,2-13H2,1H3/t14-,15?,17+,18+/m0/s1

SMILES string

CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

description

non-ionic

mol wt

346.47 g/mol

greener alternative product characteristics

Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

concentration

≥44% (GC)

greener alternative category

, Aligned

Quality Level

200

Related Categories

Application

Span 20 has been used in a study to assess enhanced solubility and oral bioavailability of itraconazole. It has also been used in a study to investigate the oxidation of unsaturated lipids in oil-in-water emulsions.

General description

Span 20 is a co-surfactant.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is 100% bio-based non-ionic surfactant, thus aligns with "Use of Renewable Feedstocks" and belongs to "12 principles aligned" category of our greener alternatives.

Other Notes

Fatty acid composition: Lauric acid (C12:0) ≥ 44%; balance primarily myristic (C14:0), palmitic (C16:0) and linolenic (C18:3) acids.

Legal Information

Span is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

>300.2 °F - closed cup

flash_point_c

> 149 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX9127
0000250318
0000250318
MKCS3076
MKCS6729

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Claire Berton et al.
Journal of colloid and interface science, 377(1), 244-250 (2012-04-25)
The development of lipid oxidation in oil-in-water (O/W) emulsions is widely influenced by the properties of the interfacial layer, which separates the oil and water phases. In this work, the effect of the structure of the interface on the oxidative
Muhammad Moniruzzaman et al.
Journal of colloid and interface science, 352(1), 136-142 (2010-09-10)
In this paper, we report a novel ionic liquid-in-oil (IL/o) microemulsion which is able to dissolve pharmaceuticals that are insoluble or sparingly soluble in water and most of pharmaceutical grade organic liquids. Towards this approach, the nanometer-sized ionic liquid droplets
Yung-Chih Kuo et al.
Colloids and surfaces. B, Biointerfaces, 76(1), 286-291 (2009-12-17)
This study analyzes the effects of Tween 80 and Span 20 on the electrical interaction between cationic solid lipid nanoparticles (CSLNs) and human brain microvascular endothelial cells (HBMECs). Electrophoretic mobility, zeta potential and fixed charge density of CSLNs and HBMECs
Pankaj Karande et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 31(1), 1-7 (2007-03-21)
Certain mixtures of chemicals are known to synergistically enhance skin permeability to drugs. Here, we report on the transport enhancing properties of mixtures of an anionic surfactant, sodium lauroylsarcosinate (NLS) and a non-ionic surfactant, sorbitan monolaurate (S20) in 1:1 phosphate
Muhammad Moniruzzaman et al.
International journal of pharmaceutics, 400(1-2), 243-250 (2010-09-04)
Pharmaceutical industries have posed challenges in the topical and transdermal administration of drugs which are poorly soluble or insoluble in water and most of organic solvents. In an approach to overcome this limitation, ionic liquid-in-oil (IL/o) microemulsions (MEs) were employed
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