Skip to Content
Merck

SAB1306484

ANTI-BECLIN 1 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

BECN1, Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, GT197, Protein GT197

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
FACS, IHC, WB
Citations:
11

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

51896 Da

species reactivity

mouse, human

technique(s)

flow cytometry: 1:10-1:50, immunohistochemistry: 1:50-1:100, western blot: 1:1000

NCBI accession no.

NP_003757.1

UniProt accession no.

Q14457

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... BECN1(8678)

Related Categories

General description

Beclin 1 (BECN1) or GT197 is a tumor suppressor gene. It is a 450 amino-acid protein having three domains. The gene encoding BECN1 is localized on human chromosome 17q21.

Application

ANTI-BECLIN 1 antibody produced in rabbit has been used for Western blotting.

Biochem/physiol Actions

Beclin 1 (BECN1) or GT197 acts as an initiator of autophagy and is vital in the early stages of autophagosome formation. It has a role in various tumors and cancers. BECN1 is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SH050527I
SA110923AU

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Polyglutamine tracts regulate beclin 1-dependent autophagy.
Ashkenazi A, et al.
Nature (2017)
The BECN1 N-terminal domain is intrinsically disordered.
Autophagy (2016)
Role of Autophagy in Breast Cancer
Vassiliki Karantza & Eileen White
Autophagy (2007)
Decreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma.
Hu Z, et al.
Molecular Medicine Reports (2016)
CISD2 promotes the proliferation of glioma cells via suppressing beclin-1-mediated autophagy and is targeted by microRNA-449a
Ai-Gang Sun, et al.
Molecular Medicine Reports (2017)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service