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Merck

SML0087

MEGX

≥95% (HPLC)

Synonym(s):

MGEX, Monoethylglycinexylidide, N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide, Norlidocaine

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About This Item

Empirical Formula (Hill Notation):
C12H18N2O
CAS Number:
7728-40-7
Molecular Weight:
206.28
NACRES:
NA.77
PubChem Substance ID:
329825147
UNSPSC Code:
12352200
MDL number:
MFCD00098991

Key Documents

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Product Name

MEGX, ≥95% (HPLC)

InChI key

WRMRXPASUROZGT-UHFFFAOYSA-N

SMILES string

CC1=C(NC(CNCC)=O)C(C)=CC=C1

InChI

1S/C12H18N2O/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3/h5-7,13H,4,8H2,1-3H3,(H,14,15)

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

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Application

MEGX has been used in an approach to improve the yield of N-dealkylated lidocaine.

Biochem/physiol Actions

Lidocaine metabolite
MEGX is generated by hepatic cytochrome P-450 system upon oxidative de-ethylation. Measurement of MEGX by immunoassay contributes to liver function test. MEGX possesses antiarrhythmic action and therefore extends lidocaine effect.
Monoethylglycinexylidide (MEGX) is an active metabolite of lidocaine.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000082911
0000082912
0000082911
0000082912
0000144607

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Robert Werdehausen et al.
Anesthesiology, 116(1), 147-158 (2011-12-03)
Lidocaine exerts antinociceptive effects when applied systemically. The mechanisms are not fully understood but glycinergic mechanisms might be involved. The synaptic glycine concentration is controlled by glycine transporters. Whereas neurons express two types of glycine transporters, astrocytes specifically express glycine
Georgette Oni et al.
Aesthetic surgery journal, 30(6), 853-858 (2010-12-07)
Topical lidocaine is a common form of anesthesia for a wealth of procedures across a large number of disciplines, including laser treatments. Preparations can be purchased over the counter with no prescription necessary. It is considered a safer and more
Hamdah M Al Nebaihi et al.
Journal of pharmaceutical sciences, 109(2), 1199-1210 (2019-11-17)
The effects of a high-fat diet on mRNA and protein of cytochrome P450 (CYP) enzymes in rats and mice and its impact on lidocaine deethylation to its main active metabolite, monoethylglycinexylidide (MEGX), in rats were investigated. The effect of a
D Venkatachalam et al.
New Zealand veterinary journal, 67(5), 228-233 (2019-04-30)
To investigate the analgesic efficacy of articaine hydrochloride for antler removal in red deer (Cervus elaphus) following S/C administration as a ring block, and to quantify the residue concentrations of articaine compared to lignocaine in the harvested antlers. Articaine hydrochloride
Dinakaran Venkatachalam et al.
Animals : an open access journal from MDPI, 8(8) (2018-08-22)
This study determined the convulsant plasma concentrations and pharmacokinetic parameters following cornual nerve block and compared the results to recommend a safe dose of lidocaine hydrochloride for goat kids. The plasma concentrations of lidocaine and monoethylglycinexylidide (MGX) were quantified using
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