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Merck

T0307

Tyloxapol

BioXtra

Synonym(s):

4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane

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About This Item

CAS Number:
25301-02-4
NACRES:
NA.25
PubChem Substance ID:
24899881
UNSPSC Code:
12161900
MDL number:
MFCD00149002

Key Documents

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Product Name

Tyloxapol, BioXtra

InChI

1S/C14H22O.C2H6O2.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;3-1-2-4;1-2/h6-9,15H,10H2,1-5H3;3-4H,1-2H2;1H2

SMILES string

[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1

InChI key

GWJOFBXSBDVUMH-UHFFFAOYSA-N

description

non-ionic

product line

BioXtra

impurities

<0.0005% Phosphorus (P)

ign. residue

<1.0%

CMC

0.018 mM

transition temp

cloud point 94.3 °C

anion traces

chloride (Cl-): <0.05%
sulfate (SO42-): <0.6%

cation traces

Al: <0.0005%
Ca: <0.0005%
Cu: <0.0005%
Fe: <0.001%
K: <0.005%
Mg: <0.0005%
NH4+: <0.05%
Na: <0.5%
Pb: <0.001%
Zn: <0.0005%

Quality Level

100

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Application

Tyloxapol has been used in a study to assess the enhanced pulmonary absorption of recombinant human insulin. It has also been used in a study to investigate the metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency.

General description

A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Used as a surfactant.
Tyloxapol is a biocompatible surfactant

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCR4287
MKCQ1034
MKCK7328
MKCH6508
MKCF6494

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Formulation of Tyloxapol niosomes for encapsulation, stabilization and dissolution of anti-tubercular drugs
Mehta, S. and N. Jindal
Colloids and Surfaces. B, Biointerfaces, 434?441-434?441 (2013)
David P Macfarlane et al.
American journal of physiology. Endocrinology and metabolism, 300(2), E402-E409 (2010-12-02)
The pathological mechanisms that distinguish simple steatosis from steatohepatitis (or NASH, with consequent risk of cirrhosis and hepatocellular cancer) remain incompletely defined. Whereas both a methionine- and choline-deficient diet (MCDD) and a choline-deficient diet (CDD) lead to hepatic triglyceride accumulation
Jianheng Zheng et al.
Die Pharmazie, 67(5), 448-451 (2012-07-07)
Natural pulmonary surfactant (PS) and its artificial substitute phospholipid hexadecanol tyloxapol (PHT) are effective absorption enhancers on promoting recombinant human insulin (Rh-ins) absorption in vivo, but the in vitro efficacy and underlying mechanism remains unclear. In the current study, the
Martina Theresa Hackl et al.
Nature communications, 10(1), 2717-2717 (2019-06-22)
Hepatic steatosis develops when lipid influx and production exceed the liver's ability to utilize/export triglycerides. Obesity promotes steatosis and is characterized by leptin resistance. A role of leptin in hepatic lipid handling is highlighted by the observation that recombinant leptin
Austin Potts et al.
American journal of physiology. Gastrointestinal and liver physiology, 315(2), G249-G258 (2018-04-11)
Cytosolic phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme that is highly expressed in the liver and kidney but is also expressed at lower levels in a variety of other tissues where it may play adjunct roles in fatty acid esterification
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