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Merck

T4509

4-Thiouridine

≥98%, synthetic (organic), powder

Synonym(s):

4sU, RNA synthesis inhibitor, Thiouridine

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About This Item

Empirical Formula (Hill Notation):
C9H12N2O5S
CAS Number:
13957-31-8
Molecular Weight:
260.27
NACRES:
NA.51
PubChem Substance ID:
24900212
UNSPSC Code:
41106305
EC Number:
237-735-3
MDL number:
MFCD00006538

Product Name

4-Thiouridine, ≥98%

InChI

1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1

InChI key

ZLOIGESWDJYCTF-XVFCMESISA-N

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=S)NC2=O

biological source

synthetic (organic)

assay

≥98%

form

powder

solubility

water: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

200

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Application

4-Thiouridine has been used in labeling and isolation of nascent RNAs.

Biochem/physiol Actions

4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.

General description

4-Thiouridine is a photoreactive uridine analog.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000523075
0000523075
0000517319
0000517319
0000497898

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Indira Memet et al.
Nucleic acids research, 45(9), 5359-5374 (2017-01-25)
In eukaryotes, the synthesis of ribosomal subunits, which involves the maturation of the ribosomal (r)RNAs and assembly of ribosomal proteins, requires the co-ordinated action of a plethora of ribosome biogenesis factors. Many of these cofactors remain to be characterized in
Tsutomu Suzuki et al.
Annual review of genetics, 45, 299-329 (2011-09-14)
Mitochondria are eukaryotic organelles that generate most of the energy in the cell by oxidative phosphorylation (OXPHOS). Each mitochondrion contains multiple copies of a closed circular double-stranded DNA genome (mtDNA). Human (mammalian) mtDNA encodes 13 essential subunits of the inner
Jonathan Krell et al.
Genome research, 26(3), 331-341 (2015-12-25)
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between
Hidenori Tani et al.
RNA biology, 9(10), 1233-1238 (2012-10-05)
Changing the abundance of transcripts by regulated RNA degradation is a critical step in the control of various biological pathways. Recently, genome-wide inhibitor-free technologies for determining RNA stabilities in mammalian cells have been developed. In these methods, endogenous RNAs are
A R Van Rompay et al.
Molecular pharmacology, 59(5), 1181-1186 (2001-04-18)
Uridine-cytidine kinases (UCK) have important roles for the phosphorylation of nucleoside analogs that are being investigated for possible use in chemotherapy of cancer. We have cloned the cDNA of two human UCKs. The approximately 30-kDa proteins, named UCK1 and UCK2
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