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About This Item
Empirical Formula (Hill Notation):
C6H8ClN7O · HCl · 2H2O
CAS Number:
Molecular Weight:
302.12
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
Product Name
Amiloride hydrochloride, United States Pharmacopeia (USP) Reference Standard
SMILES string
Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl.O.O
InChI
1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
InChI key
LTKVFMLMEYCWMK-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
amiloride
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
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Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
Amiloride hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Amiloride Hydrochloride and Hydrochlorothiazide Tablets
- Amiloride Hydrochloride Tablets
General description
Amiloride hydrochloride is a photosensitive yellow powder used as a mild diuretic drug.
Other Notes
Sales restrictions may apply.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Matthias Schoenberger et al.
Expert opinion on therapeutic patents, 23(10), 1383-1389 (2013-08-21)
Novel molecular platforms for epithelial sodium channel (ENaC) modulators are claimed in the following six patents: WO2012035158(A1); WO2009074575(A2); WO2011028740(A1); WO2009150137(A2); WO2011079087(A1); WO2008135557(A1). These ENaC inhibitors may be used in blocking transepithelial sodium and consequently water absorption across airway epithelia. This
Hector Rasgado-Flores et al.
American journal of physiology. Cell physiology, 305(11), C1114-C1122 (2013-08-30)
Hypertonic saline (HS) inhalation therapy benefits cystic fibrosis (CF) patients [Donaldson SH, Bennet WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. N Engl J Med 354: 241-250, 2006; Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, Marks
Mónica C F Ferraro et al.
Journal of pharmaceutical and biomedical analysis, 30(4), 1121-1131 (2002-11-01)
The use of multivariate spectrophotometric calibration for the simultaneous analysis of synthetic samples and commercial tablet preparations containing hydrochlorothiazide (HCT) and amiloride hydrochloride (AMH) is reported. Partial least squares (PLS-1) analysis of electronic absorption spectral data allowed the rapid and
Robert W Hunter et al.
American journal of physiology. Renal physiology, 306(4), F457-F467 (2014-01-10)
Na(+) reabsorption from the distal renal tubule involves electroneutral and electrogenic pathways, with the latter promoting K(+) excretion. The relative activities of these two pathways are tightly controlled, participating in the minute-to-minute regulation of systemic K(+) balance. The pathways are
Shujie Shi et al.
American journal of physiology. Renal physiology, 305(11), F1585-F1592 (2013-10-11)
The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (Po) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits
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