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Merck

260684

1-Deoxynojirimycin, Hydrochloride - CAS 73285-50-4 - Calbiochem

A specific glucosidase inhibitor including trimming glucosidases I and II, enzymes that sequentially remove the three glucose residues from precursor Glc3Man9-GlcNAc2 in N-linked glycan biosynthesis.

Synonym(s):

1-Deoxynojirimycin, Hydrochloride - CAS 73285-50-4 - Calbiochem, DNJ, HCl

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About This Item

Empirical Formula (Hill Notation):
C6H13NO4 · xHCl
CAS Number:
73285-50-4
Molecular Weight:
163.17 (free base basis)
UNSPSC Code:
12352200
MDL number:
MFCD00133247

Key Documents

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Product Name

1-Deoxynojirimycin, Hydrochloride - CAS 73285-50-4 - Calbiochem, A specific glucosidase inhibitor including trimming glucosidases I and II, enzymes that sequentially remove the three glucose residues from precursor Glc3Man9-GlcNAc2 in N-linked glycan biosynthesis.

assay

≥98% (TLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

water: 100 mM

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
Glucosidase 1, glucosidase 2
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Irritant (B)

General description

A specific glucosidase inhibitor including trimming glucosidases I and II, enzymes that sequentially remove the three glucose residues from precursor Glc3Man9-GlcNAc2 in N-linked glycan biosynthesis.
Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc3Man9GlcNAc2 in N-linked glycan biosynthesis.

Other Notes

Suh, K., et al. 1992. J. Biol. Chem. 267, 21671.
Fuhrmann, U., et al. 1985. Biochim. Biophys. Acta825, 95.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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K Suh et al.
The Journal of biological chemistry, 267(30), 21671-21677 (1992-10-25)
The role of glucosylated oligosaccharides in the biogenesis of the glycoprotein (G protein) of vesicular stomatitis virus was studied in PhaR2.7, a mouse lymphoma cell line deficient in glucosidase II activity. As expected, the great majority of cell-associated G protein
Inhibitors of oligosaccharide processing.
U Fuhrmann et al.
Biochimica et biophysica acta, 825(2), 95-110 (1985-06-24)

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