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A9525

Angiotensin II human

Name: Angiotensin II human
Brand: SIGMA

≥93% (HPLC), powder

Synonym(s):

1-8-AngiotensinI, 5-Isoleucine-angiotensinII, Ang II, Angiotensin 2, Angiotensin II, DRVYIHPF, Hypertensin, Ile(5)-angiotensinII

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About This Item

Empirical Formula (Hill Notation):

C₅₀H₇₁N₁₃O₁₂

CAS Number:

4474-91-3

Molecular Weight:

1046.18

MDL number:

MFCD00161484

UNSPSC Code:

12352202

eCl@ss:

42020611

PubChem Substance ID:

24891466

NACRES:

NA.32

Form:

powder

Assay:

≥93% (HPLC)

Biological source:

synthetic

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Properties

biological source

synthetic

Quality Level

300

assay

≥93% (HPLC)

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

concentration

≤100%

technique(s)

cell culture | mammalian: suitable

impurities

1.2-10.4% acetate

solubility

water: 25 mg/mL, clear, colorless

UniProt accession no.

P01019

storage temp.

−20°C

SMILES string

[nH]1cncc1C[C@H](NC(=O)C(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)CCCNC(=N)N)C(C)C)Cc4ccc(cc4)O)[C@H](CC)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](Cc3ccccc3)C(=O)O

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

Gene Information

human ... AGT(183)

Description

General description

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH₃COOH · H₂O

Research area: Cell Signaling

Application

Angiotensin II (angII) human has been used:
to study its effect on interleukin-1β–mediated islet inflammation and β-cell dysfunction.
to determine if angII activates specific calcineurin-dependent NFAT (nuclear factor of activated T-cells) isoforms in cardiomyocytes.
to study the actions of systemic angII infusions on glomerular permeability in vivo.
to induce abdominal aortic aneurysms (AAAs) in ApoE knockout mice for experimental studies.
to study the effect of Ang II infusion on atrial branched-chain amino acids (BCAAs) catabolism in male C57/BL6 mice.
to check the effects of angII on plasma triglyceride production and its association with insulin resistance in normal rats.

Biochem/physiol Actions

Angiotensin II (angII) is an octapeptide cardiovascular hormone which affects the activities of the heart, kidney, vasculature and brain. AngII in the blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, and modulation of myocardial hypertrophy, renal failure and fibrosisAngII plays a key role in the regulation of blood pressure via the renin-angiotensin-aldosterone (RAAS) pathway.

Features and Benefits

The purity of our angiotensin II human, Ang II, is verified to assure your experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.

Analysis Note

Peptide content not less than 75%

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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