P3635
5β-Pregnane-3α,20α-diol glucuronide
≥98.00% (TLC), powder, progesterone metabolite
Synonym(s):
P3G, PDG, Pn3-G, Pregnanediol-3a-glucuronide, Pregnanediol-glucuronide, 3α,20α-Dihydroxy-5β-pregnane 3-glucuronide
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About This Item
Empirical Formula (Hill Notation):
C27H44O8
CAS Number:
Molecular Weight:
496.63
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
5β-Pregnane-3α,20α-diol glucuronide,
sterility
non-sterile
Quality Level
assay
≥98.00% (TLC)
form
powder
technique(s)
enzyme immunoassay: suitable
solubility
ethanol: 20 mg/mL, clear, colorless
shipped in
ambient
storage temp.
−20°C
SMILES string
CC(O)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC5OC(C(O)C(O)C5O)C(O)=O
InChI
1S/C27H44O8/c1-13(28)17-6-7-18-16-5-4-14-12-15(8-10-26(14,2)19(16)9-11-27(17,18)3)34-25-22(31)20(29)21(30)23(35-25)24(32)33/h13-23,25,28-31H,4-12H2,1-3H3,(H,32,33)
InChI key
ZFFFJLDTCLJDHL-UHFFFAOYSA-N
General description
5β-Pregnane-3α,20α-diol glucuronide is a progesterone metabolite predominant in urine, during pregnancy. Presence of 5β-Pregnane-3α,20α-diol glucuronide in the urine indicates pregnancy, but it might also account for pseudopregnancy. It is useful in predicting the delivery time/end of pseudopregnancy.
Urinary pregnanediol glucuronide (PdG) seems to serve as an effective clinical marker for monitoring progesterone supplementation. PdG, along with other urinary metabolites such as luteinizing hormone (LH), follicle stimulating hormone (FSH), and estrone glucuronide (ElG), exhibit a strong association with ovarian excretion rates and demonstrate a high correlation with serum reproductive hormones. As a result, they can be used interchangeably to effectively monitor ovarian steroidogenesis.
Application
5β-Pregnane-3α,20α-diol glucuronide has been used in a cross-sectional analysis of hormone levels. It has also been used as a standard to measure estradiol-17β, pregnanediol-glucuronide (PdG) by a double-antibody enzyme immunoassay.
5β-Pregnane-3α,20α-diol glucuronide has been used in steroid enzyme immunoassay.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Chest Pain with Normal Coronary Arteries: A Multidisciplinary Approach, 323-323 (2013)
Jennifer E Mersereau et al.
Menopause (New York, N.Y.), 15(3), 482-486 (2008-01-19)
To compare daily reproductive hormone secretion in regularly menstruating older versus younger women. This was a prospective cohort study. Daily morning urine samples were obtained from 106 women, 28 of whom were aged between 20 and 34 years (mean: 27.8+/-3.7
Characterization of the ovarian cycle in the two-toed sloths (Choloepus didactylus): an innovative, reliable, and noninvasive method using fecal hormone analyses
Troll S, et al.
Theriogenology (2013)