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OP53 Anti-c-Fos (Ab-3) Mouse mAb (CS93.1.18)

Anti-c-Fos (Ab-3) Mouse mAb (CS93.1.18) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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OP53
  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      H, MMMonoclonal Antibody
      Description
      Overview

      This product has been discontinued.



      Recognizes the ~50-62 kDa c-Fos protein in serum-stimulated NIH3T3 cells and A431 cells. Also recognizes v-fos.
      Catalogue NumberOP53
      Brand Family Calbiochem®
      References
      ReferencesRouscher III, F.J., et al. 1988. Science 240, 1010.
      Sassone-Corsi, P., et al. 1988. Cell 54, 553.
      Verma, I.M., and Graham, W.R.,1987. Adv. Cancer Res. 49, 29.
      Verma, I.M., and Sassone-Corsi, P., 1987. Cell 52, 513).
      Muller, R., 1986. Biochim. Biophys. Acta 823, 207.
      Verma, I.M., 1986. Trends Genet. 2, 93.
      Greenberg, M., and Ziff, E., 1984. Nature, London 311, 433.
      Product Information
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 50% glycerol.
      Negative controlGrowth-arrested cells
      Positive controlSerum-stimulated NIH 3T3 cells or A431 cells
      PreservativeNone
      Quality LevelMQ100
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Paraffin Sections
      Application NotesImmunoblotting (1-5 µg/ml)
      Paraffin Sections (1-10 µg/ml; pepsin pre-treatment required)
      Application CommentsThis antibody will react with both cellular and viral forms of Fos. The immunogen c-Fos (Peptide-2), Cat. No. PP10, is also available for competition studies. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide (SGFNADYEASSSRC) (Cat. No. PP10) corresponding to amino acids 4-17 of human c-Fos
      ImmunogenHuman
      CloneCS93.1.18
      HostMouse
      IsotypeIgG₁
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      OP53 0

      Documentation

      Anti-c-Fos (Ab-3) Mouse mAb (CS93.1.18) MSDS

      Title

      Safety Data Sheet (SDS) 

      Anti-c-Fos (Ab-3) Mouse mAb (CS93.1.18) Certificates of Analysis

      TitleLot Number
      OP53

      References

      Reference overview
      Rouscher III, F.J., et al. 1988. Science 240, 1010.
      Sassone-Corsi, P., et al. 1988. Cell 54, 553.
      Verma, I.M., and Graham, W.R.,1987. Adv. Cancer Res. 49, 29.
      Verma, I.M., and Sassone-Corsi, P., 1987. Cell 52, 513).
      Muller, R., 1986. Biochim. Biophys. Acta 823, 207.
      Verma, I.M., 1986. Trends Genet. 2, 93.
      Greenberg, M., and Ziff, E., 1984. Nature, London 311, 433.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2007 RFH
      ApplicationImmunoblotting (1-5 µg/ml)
      Paraffin Sections (1-10 µg/ml; pepsin pre-treatment required)
      DescriptionPurified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with SP2/0-AG14 plasmacytoma cells. Recognizes the ~50-62 kDa Fos protein.
      BackgroundThe proto-oncogene fos has been implicated in cell growth, differentiation and development. c-Fos is induced by a large number of stimuli including from mitogens, differentiation-specific agents and pharmacological agents. Induction of the 62 kDa Fos protein is rapid but transient. The Fos protein is associated with a 39 kDa protein which has been identified as the protein product of the Jun proto-oncogene (c-jun). The Fos/Jun protein complex binds specifically to a sequence element in DNA referred to as the AP-1 binding site.
      HostMouse
      Immunogen speciesHuman
      Immunogena synthetic peptide (SGFNADYEASSSRC) (Cat. No. PP10) corresponding to amino acids 4-17 of human c-Fos
      CloneCS93.1.18
      IsotypeIgG₁
      Specieshuman, mouse
      Positive controlSerum-stimulated NIH 3T3 cells or A431 cells
      Negative controlGrowth-arrested cells
      FormLiquid
      FormulationIn 0.05 M sodium phosphate buffer, 50% glycerol.
      Concentration Label Please refer to vial label for lot-specific concentration
      PreservativeNone
      CommentsThis antibody will react with both cellular and viral forms of Fos. The immunogen c-Fos (Peptide-2), Cat. No. PP10, is also available for competition studies. Antibody should be titrated for optimal results in individual systems.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesRouscher III, F.J., et al. 1988. Science 240, 1010.
      Sassone-Corsi, P., et al. 1988. Cell 54, 553.
      Verma, I.M., and Graham, W.R.,1987. Adv. Cancer Res. 49, 29.
      Verma, I.M., and Sassone-Corsi, P., 1987. Cell 52, 513).
      Muller, R., 1986. Biochim. Biophys. Acta 823, 207.
      Verma, I.M., 1986. Trends Genet. 2, 93.
      Greenberg, M., and Ziff, E., 1984. Nature, London 311, 433.