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504462 InSolution™ Wnt Antagonist I, IWR-1-endo - CAS 1127442-82-3 - Calbiochem

504462
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Key Spec Table

Empirical FormulaCAS #
C₂₅H₁₉N₃O₃ 1127442-82-3

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      Description
      Catalogue Number504462
      Brand Family Calbiochem®
      SynonymsInhibitor of Wnt Response-1, TNKS1/2 Inhibitor II, Tankyrase1/2 Inhibitor II, Wnt Pathway Inhibitor I
      References
      ReferencesWang, H., et al. 2011. ACS Chem. Biol. 6, 192.
      Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
      Huang, S.M., et al. 2009. Nature 461, 614.
      Product Information
      CAS number1127442-82-3
      FormLiquid
      FormulationA 25 mM (5 mg/489 µL) solution of Wnt Antagonist I, IWR-1-endo (Cat. No. 681669) in DMSO.
      Hill FormulaC₂₅H₁₉N₃O₃
      Chemical formulaC₂₅H₁₉N₃O₃
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAxin
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Wnt Antagonist I, IWR-1-endo - CAS 1127442-82-3 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Wang, H., et al. 2011. ACS Chem. Biol. 6, 192.
      Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
      Huang, S.M., et al. 2009. Nature 461, 614.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-June-2013 JSW
      SynonymsInhibitor of Wnt Response-1, TNKS1/2 Inhibitor II, Tankyrase1/2 Inhibitor II, Wnt Pathway Inhibitor I
      DescriptionA cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 µM). Although both IWR-1-endo and XAV939 (Tankyrase1/2 Inhibitor; Cat. No. 575545) act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.
      FormLiquid
      FormulationA 25 mM (5 mg/489 µL) solution of Wnt Antagonist I, IWR-1-endo (Cat. No. 681669) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1127442-82-3
      Chemical formulaC₂₅H₁₉N₃O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Toxicity Irritant
      ReferencesWang, H., et al. 2011. ACS Chem. Biol. 6, 192.
      Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
      Huang, S.M., et al. 2009. Nature 461, 614.