1.12120
Calcium carbonate
precipitated (≤ 0.0001% Al), EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 170
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About This Item
Linear Formula:
CaCO3
CAS Number:
Molecular Weight:
100.09
UNSPSC Code:
12352302
EC Index Number:
207-439-9
E Number:
E170
MDL number:
Beilstein/REAXYS Number:
8008338
Quality Level
agency
BP, JP, Ph. Eur., USP
reg. compliance
FCC
product line
EMPROVE® ESSENTIAL
form
solid
potency
6450 mg/kg LD50, oral (Rat), >2000 mg/kg LD50, skin (Rat)
pH
9.5-10.5 (20 °C, 100 g/L in H2O, slurry)
mp
825 °C (decomposition)
density
2.93 g/mL at 25 °C (lit.)
application(s)
liquid formulation
pharmaceutical
solid formulation
storage temp.
2-30°C
SMILES string
[Ca++].[O-]C([O-])=O
InChI
1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
InChI key
VTYYLEPIZMXCLO-UHFFFAOYSA-L
General description
Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Application
Calcium carbonate is typically used as alkalizer or mineral supplement in solid formulations. The low aluminum content is relevant for baby food application.
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
13 - Non Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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J P Hilton-Proctor et al.
European journal of medicinal chemistry, 191, 112120-112120 (2020-03-03)
N-Methylpyrrolidone is one of several chemotypes that have been described as a mimetic of acetyl-lysine in the development of bromodomain inhibitors. In this paper, we describe the synthesis of a 4-phenyl substituted analogue - 1-methyl-4-phenylpyrrolidin-2-one - and the use of