C1240
Chlormethiazole hydrochloride
≥98% (HPLC), GABAA agonist, powder
Synonym(s):
4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C6H8ClNS · HCl
CAS Number:
Molecular Weight:
198.11
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Chlormethiazole hydrochloride, ≥98% (HPLC), powder
description
Store desiccated
Quality Level
assay
≥98% (HPLC)
form
powder
color
off-white
solubility
H2O: soluble >10 mg/mL
originator
AstraZeneca
SMILES string
Cl.Cc1ncsc1CCCl
InChI
1S/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H
InChI key
OFXYKSLKNMTBHK-UHFFFAOYSA-N
Biochem/physiol Actions
GABAA agonist; glycine receptor modulator.
Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug.
Features and Benefits
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
M Gasior et al.
The Journal of pharmacology and experimental therapeutics, 295(1), 153-161 (2000-09-19)
Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and ethanol withdrawal syndrome). On account of several experimental and clinical studies reporting effectiveness against the toxic effects
Rachael M Nelson et al.
European journal of pharmacology, 452(3), 255-262 (2002-10-03)
Clomethiazole is a gamma-aminobutyric acid (GABA)-mimetic agent with anticonvulsant, sedative and neuroprotective properties. The pharmacological actions of clomethiazole that underlie its functional profile have not been fully explored, but are known to result from an interaction with the GABA(A) receptor.
Pediatric Critical Care Medicine: Basic Science And Clinical Evidence, 985-985 (2007)