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Merck

M22601

1-(2-Methoxyphenyl)piperazine

98%

Synonym(s):

1-(2-Methoxyphenyl)piperazine, 1-(o-Anisyl)piperazine, 1-(o-Methoxyphenyl)piperazine, N-(2-Methoxyphenyl)piperazine, N-(o-Methoxyphenyl)piperazine, o-Methoxyphenylpiperazine

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About This Item

Empirical Formula (Hill Notation):
C11H16N2O
CAS Number:
35386-24-4
Molecular Weight:
192.26
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24896714
EC Number:
252-537-7
Beilstein/REAXYS Number:
167888
MDL number:
MFCD00005958
Assay:
98%

Key Documents

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InChI key

VNZLQLYBRIOLFZ-UHFFFAOYSA-N

InChI

1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3

SMILES string

COc1ccccc1N2CCNCC2

assay

98%

refractive index

n20/D 1.575 (lit.)

bp

130-133 °C/0.1 mmHg (lit.)

mp

35-40 °C (lit.)

density

1.095 g/mL at 25 °C (lit.)

Quality Level

100

Gene Information

mouse ... Htr3a(15561)
rat ... Adra1a(29412), Drd2(24318), Htr1a(24473), Htr2a(29595), Htr7(65032)

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Application

1-(2-Methoxyphenyl)piperazine can be used:
  • To functionalize pyrazolylvinyl ketones via Aza-Michael addition reaction.
  • To prepare cyclic amine substituted Tröger′s base derivatives.
  • To prepare functionalized bis(mercaptoimidazolyl)borates by reacting with the activated ester, [(1-methyl-2-mercaptoimidazol-5-yl)carbonyl]succinimide.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
STBL2222
STBJ5077
STBG9925
STBF5530V
STBD0689V

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Mehtap Tugrak et al.
Bioorganic chemistry, 90, 103095-103095 (2019-07-10)
New mono Mannich bases, (2-(4-hydroxy-3-((4-substituephenylpiperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-one), were prepared to evaluate their cytotoxic/anticancer properties and also their inhibitory effects on human carbonic anhydrase I and II isoenzymes (hCA I and II). Amine part was changed as [N-phenylpiperazine (1), N-benzylpiperazine (2), 1-(2-fluorophenyl)piperazine (3)
Jan Boksa et al.
Polish journal of pharmacology, 55(6), 1013-1019 (2004-01-20)
A series of 15 new 2-H- and 2-substituted 5-[omega-[4-(2-methoxyphenyl)-piperazinyl]-alkyl]-1,2,3,4-tetrahydro-gamma-carboline derivatives were prepared, and their affinity for 5-HT1A and 5-HT2A serotonin receptors was determined. Most of those hybrid compounds were found to bind with high affinity to 5-HT1A sites (Ki <
Christian Mattsson et al.
International journal of hygiene and environmental health, 211(3-4), 458-462 (2007-09-18)
Occupational exposure to toluene diisocyanate (TDI) is a known occupational hazard and the occupational exposure limits in air are very low. One of the most common methods to monitor exposure to isocyanates is to sample air through filters impregnated with
Rhenium (I) tricarbonyl complexes with mercaptoimidazolylborate ligands bearing piperazine fragments
Garcia R, et al.
J. Chem. Soc., Dalton Trans., 6(22), 4236-4241 (2002)
CuI-catalyzed amination of Troger′s base halides: a convenient method for synthesis of unsymmetrical Troger′s bases
Reddy MB, et al.
Royal Society of Chemistry Advances, 6(100), 98297-98305 (2016)
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