A0752
Adenosine 5′-diphosphoribose sodium salt
≥93%, from yeast (candida utilis), powder
Synonym(s):
ADPR, ADP-Ribose
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About This Item
Empirical Formula (Hill Notation):
C15H23N5O14P2
CAS Number:
Molecular Weight:
559.32
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
Assay:
≥93%
Biological source:
yeast (candida utilis)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
Product Name
Adenosine 5′-diphosphoribose sodium salt, ≥93%
biological source
yeast (candida utilis)
Quality Level
assay
≥93%
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C3O
InChI
1S/C15H23N5O14P2.Na.H/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);;
InChI key
NWPVXDZLQTURKI-UHFFFAOYSA-N
Application
5′-Deoxy-5′-(methylthio)adenosine has been used:
- to give a range of nicotinamide adenine dinucleotide (NADH)
- oxidation rates for the respiratory complex (CI/CIII/CIV)
- CI/alternative(AOX) pathway
- to measure poly(ADP-ribose) glycohydrolaseactivity
- poly(ADP-ribose) (PAR) binding competition assay
- oxidase (AOX) pathway
- to measure poly(ADP-ribose) glycohydrolase activity
- poly(ADP-ribose) (PAR) binding competition assay
Biochem/physiol Actions
Adenosine5′-diphosphoribose (ADP-Ribose) is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are important components of DNA repair and apoptosis signaling. ADP-Ribose initiates the transient receptor potential subfamily melastatin, type2 (TRPM2), a Na+, Ca2+, and K+ cation channel.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Byung Kil Park et al.
International journal of radiation biology, 95(8), 1094-1102 (2019-03-05)
Purpose: The present study aimed to investigate the potential protective effects of icariin both in vivo and in vitro, an active flavonoid glucoside derived from medicinal herb Epimedium, and its possible mechanisms against radiation-induced injury. Methods: Male C57BL/6 mice were
Marcos Roberto de Oliveira et al.
Journal of molecular neuroscience : MN, 69(1), 115-122 (2019-05-28)
Redox impairment, inflammation, and increased rates of cell death are central players during neurodegeneration. In that context, activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has been viewed as an interesting strategy in order to reduce
Monitoring poly (ADP-ribosyl) glycohydrolase activity with a continuous fluorescent substrate
Drown BS, et al.
Cell Chemical Biology, 25(12), 1562-1570 (2018)