H7891
Hexammine cobalt(III) chloride
for use in transformations, X-ray crystallography and NMR
Synonym(s):
Cobalt hexammine trichloride, Hexaamminecobalt trichloride
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About This Item
Linear Formula:
[Co(NH3)6]Cl3
CAS Number:
Molecular Weight:
267.48
NACRES:
NA.52
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
234-103-9
MDL number:
InChI key
JXBGZYGSWFSYFI-UHFFFAOYSA-K
InChI
1S/3ClH.Co.6H3N/h3*1H;;6*1H3/q;;;+3;;;;;;/p-3
SMILES string
N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Co+3]
grade
Molecular Biology
form
powder
storage temp.
room temp
Quality Level
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General description
Hexammine cobalt(III) is considered an analog of fully solvated magnesium, capable of activating some enzymes that requires magnesium. It is useful in DNA condensation studies.
Application
Suitable for
- DNA condensation studies
- induction of transitions of DNA from B to A or Z forms
- induction of nucleic acid crystal growth
- stabilization of tertiary tRNA interactions
- preparation of ligation buffer
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 4 - Carc. 2 - Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Filip Senigl et al.
Cell reports, 29(12), 3902-3915 (2019-12-19)
Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. We have used lentiviral SHM reporter vectors to identify regions of the genome that are susceptible ("hot") and resistant ("cold")
Tong Zhang et al.
PloS one, 7(8), e43872-e43872 (2012-09-07)
Crystal structures of Thermotoga maritima magnesium transporter CorA, reported in 2006, revealed its homo-pentameric constructions. However, the structure of the highly conserved extracellular interhelical loops remains unsolved, due to its high flexibility. We have explored the configurations of the loops
G Soslau et al.
Nucleic acids research, 14(18), 7237-7252 (1986-09-25)
These studies employed the synthetic linear DNA, poly dGdC, in the B and cobalt hexammine chloride (Co)-induced Z form to determine the effect of conformation on protein-DNA interactions. The rate of the reaction of the restriction endonucleases, Hha I and
Tumpa Sarkar et al.
Nucleic acids research, 33(1), 143-151 (2005-01-11)
The condensation of nucleic acids into well-defined particles is an integral part of several approaches to artificial cellular delivery. Improvements in the efficiency of nucleic acid delivery in vivo are important for the development of DNA- and RNA-based therapeutics. Presently
K E Rao et al.
Journal of biomolecular structure & dynamics, 7(2), 335-345 (1989-10-01)
Interaction of the DNA binding nonintercalators Netropsin, Distamycin and the mPD derivative with Z-DNA has been studied. It has been found that environmental factors like the solvent and added cations significantly modulate the interaction of these ligands with Z-DNA. However
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