P3415
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
≥95%, powder
Synonym(s):
N-Succinimidyl 3-(2-pyridyldithio)propionate, SPDP
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About This Item
Empirical Formula (Hill Notation):
C12H12N2O4S2
CAS Number:
Molecular Weight:
312.36
UNSPSC Code:
12352106
NACRES:
NC.07
PubChem Substance ID:
EC Number:
269-034-3
Beilstein/REAXYS Number:
1548137
MDL number:
Assay:
≥95%
Form:
powder
InChI key
JWDFQMWEFLOOED-UHFFFAOYSA-N
InChI
1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
SMILES string
O=C(CCSSC1=NC=CC=C1)ON2C(CCC2=O)=O
assay
≥95%
form
powder
reaction suitability
reagent type: cross-linking reagent
mp
84-86 °C (lit.)
solubility
acetone: 50 mg/mL, DMF: soluble
functional group
NHS ester
storage temp.
−20°C
Quality Level
Related Categories
General description
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.
Application
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
It has been used for antibody conjugation and as a protein cross-linker.
It has been used for antibody conjugation and as a protein cross-linker.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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