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Merck

R9525

RX 821002 hydrochloride

solid, ≥98% (HPLC)

Synonym(s):

2-[2-(2-Methoxy-1,4-benzodioxanyl)]imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H14N2O3 · HCl
CAS Number:
109544-45-8
Molecular Weight:
270.71
NACRES:
NA.77
PubChem Substance ID:
24278684
UNSPSC Code:
12352200
MDL number:
MFCD00069343

Key Documents

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InChI

1S/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H

SMILES string

Cl[H].COC1(COc2ccccc2O1)C3=NCCN3

InChI key

IMPOOMVZVWKSAP-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: >20 mg/mL

Quality Level

100

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Biochem/physiol Actions

Selective α2-adrenoceptor antagonist

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000395015
0000395015
0000158506
0000102041

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J Galitzky et al.
British journal of pharmacology, 100(4), 862-866 (1990-08-01)
1. The binding of a new alpha 2-adrenoceptor antagonist, [3H]-RX821002 (2-(2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline), was investigated in human platelet membranes and compared with [3H]-yohimbine binding parameters. 2. Analysis of kinetic data revealed association and dissociation time courses consistent with a simple biomolecular reaction.
S J Rayment et al.
British journal of pharmacology, 160(7), 1727-1740 (2010-07-24)
We have investigated the distribution of alpha-adrenoceptors in sheep internal anal sphincter (IAS), as a model for the human tissue, and evaluated various imidazoline derivatives for potential treatment of faecal incontinence. Saturation and competition binding with (3)H-prazosin and (3)H-RX821002 were
S Gasparini et al.
Neuroscience, 164(2), 370-379 (2009-09-01)
The blockade of serotoninergic receptors with methysergide or the activation of alpha(2)-adrenoceptors with moxonidine into the lateral parabrachial nucleus (LPBN) increases water and 0.3 M NaCl intake in rats treated with furosemide (FURO) combined with captopril (CAP). In the present
Mercè Masana et al.
The international journal of neuropsychopharmacology, 14(1), 53-68 (2010-08-13)
The superior efficacy of atypical vs. classical antipsychotic drugs to treat negative symptoms and cognitive deficits in schizophrenia appears related to their ability to enhance mesocortical dopamine (DA) function. Given that noradrenergic (NE) transmission contributes to cortical DA output, we
Axel Rominger et al.
Synapse (New York, N.Y.), 64(8), 654-657 (2010-03-26)
To test for alpha(2) adrenergic modulation of dopamine D(2/3) receptor availability in striatum of living mice using the high-affinity ligand [(18)F]fallypride and microPET. Groups of anesthetized mice were pretreated with saline, the alpha(2)-agonist clonidine (1 mg/kg), and the alpha(2)-antagonists RX821002
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